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The changeable nervous system: Studies on neuroplasticity in cerebellar cultures
2014, Neuroscience and Biobehavioral ReviewsCitation Excerpt :A follow-up quantitative study affirmed a three- to four-fold increase in the number of surviving large cortical neurons (Seil, 1987). In spite of the absence of parallel fibers, Purkinje cell dendrites were studded with spines (Seil et al., 1980). The numbers of Purkinje cell axons and especially axon collaterals were markedly increased, but were not myelinated.
Intrinsic versus extrinsic determinants during the development of Purkinje cell dendrites
2009, NeuroscienceCitation Excerpt :Experiments performed many years ago allowed us to assume that climbing fibers are essential for this compartmentalization of PC dendrites, since if climbing fibers are removed either during development (Sotelo and Arsenio-Nunes, 1976) or in adult animals (Sotelo et al., 1975), the thorns, stubby spines, disappear, and numerous new long-necked spines, similar to those present in the distal compartment, emerge all along the proximal branches. In the same fashion, in organotypic culture, a system devoid of climbing fibers, PCs bear numerous spines throughout their dendritic tree (Seil et al., 1980; Dusart et al., 1997). These results suggest that climbing fibers, the first afferent axons to contact PCs (Sotelo, 2008), exert a strong repressive influence on their postsynaptic domain, preventing it from being contacted by parallel fibers.
Heterogeneity of NG2-expressing cells in the newborn mouse cerebellum
2005, Developmental BiologyCellular and molecular control of dendritic growth and development of cerebellar Purkinje cells
2004, Progress in Histochemistry and Cytochemistry