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Cited by (64)
Intra-axonal protein synthesis in development and beyond
2016, International Journal of Developmental NeuroscienceCitation Excerpt :As a consequence, it can take days for somatically derived proteins to reach their targets in distal axons, raising the issue of protein stability during these long transport times. Slowly transported proteins are indeed degraded over time within mouse retinal ganglion axons (Nixon, 1980). Based on these considerations, the hypothesis was formulated that axonal protein synthesis was needed to overcome the slow transport rates of proteins from the neuronal cell bodies (Alvarez, 1992).
Does metabolic failure at the synapse cause Alzheimer's disease?
2014, Medical HypothesesCitation Excerpt :In the longest axons these speeds represent transport times of days for mitochondria and weeks for proteins. In view of estimated mitochondrial half lives of 10–25 days, and average axonal protein half lives of 1.8 days both proteins and mitochondria could be substantially degraded before reaching their destinations [79,80]. Consideration of large mammals illuminates this problem.
Protein synthesis in axons and terminals: Significance for maintenance, plasticity and regulation of phenotypeWith a critique of slow transport theory
2000, Progress in NeurobiologyCitation Excerpt :Confirming these expectations, inhibition of protein synthesis for a week, which reduced axonal microtubules by half in a reversible manner, had no effect on the microtubule content in adjacent untreated segments. The reduction was consistent with an estimated tubulin half-life of 10 days in brain, axons, and terminals (Karlsson and Sjöstrand, 1971b; Forgue and Dahl, 1978; Nixon, 1980). To explain the taxol induced increase in microtubule content, the mere promotion of assembly by this drug as a mechanism does not appear to be sufficient, owing to the latency of several days, and the inordinately large pool of soluble subunits required.
Protein-synthesizing machinery in the axon compartment
1999, NeuroscienceThe axon as a metabolic compartment: Protein degradation, transport, and maximum length of an axon
1997, Journal of Theoretical Biology
A preliminary report of this work has appeared.