Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion
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2011, Life SciencesCitation Excerpt :Various data show that the extracellular Glu and Asp concentrations increase during the ischemic period while decreasing rapidly upon onset of reperfusion (Molchanova et al. 2004; Ritz et al. 2008). Increased Glu levels may lead to the opening of the BBB in cerebral ischemia (András et al. 2007), subsequently causing the excessive efflux of excitatory amino acids from the brain to peripheral circulation during reperfusion termed “washed-out” (Erecińska et al. 1984). This is indicated by the findings that the onset of excitatory amino acids elevation in serum began 4–6 h after ischemic induction (Puig et al. 2000).
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2011, Brain ResearchCitation Excerpt :These GLU and GLN concentrations in KA rats were significantly lower than those in normal hippocampus (p < 0.01) as shown in the Table. The values in normal hippocampus measured in our laboratory were very close to those reported in literature (Erecińska et al., 1984). In KA rats of Seizure Group, we observed 2- to 6-fold (mean ± SEM of 4.0 ± 0.6 fold) elevation of GLUECF.
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