Studies on the mechanism of tolerance to methamphetamine
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Cited by (39)
Investigating the microstructural and neurochemical environment within the basal ganglia of current methamphetamine abusers
2015, Drug and Alcohol DependenceCitation Excerpt :However, because microglia have been shown to develop tolerance to provocative stimuli (Ajmone-Cat et al., 2003), it is possible that microglia may also develop tolerance to methamphetamine and subsequently produce fewer of the inflammatory mediators that are thought to precipitate neuronal damage (Thomas and Kuhn, 2005). There is considerable evidence that methamphetamine use in humans often begins with a period of gradual dose escalation, resulting in the development of tolerance (Cook et al., 1992; Fischman and Schuster, 1974; Schmidt et al., 1985); it is possible that this tolerance is maintained, or even further developed, as long as active drug use is continued. As all the participants in this current study were actively using, it is possible that the microglial activation normally observed in the basal ganglia following methamphetamine exposure could be attenuated, resulting in a diminished inflammatory response and the absence of diffusion abnormalities.
Juvenile exposure to methamphetamine attenuates behavioral and neurochemical responses to methamphetamine in adult rats
2012, Behavioural Brain ResearchCitation Excerpt :Another possible mechanism underlying the attenuated DA response could be changes in pharmacokinetics. MA pretreatments can lead to decreased MA and amphetamine concentrations within the brain following some protocols [42, but see 43]. If exposure to MA during preadolescence led to decreased brain concentrations when exposed to MA as adults, decreased DA release and locomotor responses may occur.
Persistence of tolerance to methamphetamine-induced monoamine deficits
2007, European Journal of PharmacologySex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
2005, Toxicology and Applied PharmacologyMonoclonal IgG affinity and treatment time alters antagonism of (+)-methamphetamine effects in rats
2005, European Journal of PharmacologyAcute and chronic continuous methamphetamine have different long-term behavioral and neurochemical consequences
2005, Neurochemistry International