Induction of epileptiform activity in hippocampal slices by trains of electrical stimuli

doi:10.1016/0006-8993(85)90807-8

Brain Research

Volume 344, Issue 2, 7 October 1985, Pages 296-302

https://doi.org/10.1016/0006-8993(85)90807-8 Get rights and content

Abstract

In this paper we present an in vitro model of epileptogenesis based on electrical stimulation rather than pharmacological or ionic manipulations. Hippocampal slices given a series trains similar to those used in kindling ezhibited 3 types of epileptiform activity in CA3: (1) afterdischarges immediately following the trains; (2) spontaneous bursts of multiple population spikes; and (3) bursts triggered by single stimuli. The afterdischarges and spontaneous bursts may be comparable to those seen in vivo during kindling; also, the progression of these features in this model was similar to their progression during kindlilng. All epileptiform activities were long-lasting, persisting for up to 3.5 h following the last train. This stimulus train-induced population bursting should be valuable as an acute model of hippocampal epileptogenesis, and may also help elucidate hippocampal participation in the kindling process.

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Induction of epileptiform activity in hippocampal slices by trains of electrical stimuli

Abstract

Exp. Neurol.

Electroenceph. clin. Neurophysiol.

Exp. Neurol.

Brain Research

Exp. Neurol.

Progress in Neurobiol.

Brain Research

J. Neurosci. Meth.

Exp. Neurol.

Brain Research

Brain Research

Brain Research

Brain Research

Brain Research

Brain Res. Bull.

Neurosci. Lett.

Brain Research

Develop. Brain Res.

Exp. Neurol.