In vivo voltammetric characterization of low affinity striatal dopamine uptake: Drug inhibition profile and relation to dopaminergic innervation density

doi:10.1016/0006-8993(86)90318-5

Brain Research

Volume 373, Issues 1–2, 14 May 1986, Pages 85-91

https://doi.org/10.1016/0006-8993(86)90318-5 Get rights and content

Abstract

Electrical stimulation of the median forebrain bundle evoked dopamine release in the ipsilateral striatum which was monitored with high-speed cyclic voltammetry. After stimulation, the extracellular concentration of dopamine fell due to uptake in a biphasic manner, showing zero-order and first-order components. The zero-order phase corresponded to a V_max of 42.8 ± 1.8nmol/min/g tissue. The uptake system could be blocked by d-amphetamine, methylphenidate and nomifensine, but not by benztropine, amfonelic acid or mazindol. The density of uptake sites showed a correlation with the density of striatal dopamine innervation.

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In vivo voltammetric characterization of low affinity striatal dopamine uptake: Drug inhibition profile and relation to dopaminergic innervation density

Abstract

J. Neurosci. Meth.

J. Neurosci. Meth.

Brain Research

Eur. J. Pharmacol.

Eur. J. Pharmacol.

Biochem. Pharmacol.

Life Sci.

Biochem. Pharmacol.

Brain Research

Eur. J. Pharmacol.

Brain Research

Brain Research

Brain Research

Neurosci. Lett.

Brain Research

Pharmacol. Biochem. Behav.