Research reportCochicine-induced granule cell loss in rat hippocampus: Selective behavioral and histological alterations
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The fasciola cinereum subregion of the hippocampus is important for the acquisition of visual contextual memory
2022, Progress in NeurobiologyCitation Excerpt :Given the prominent efferent projections from the FC to the DG identified in our study, we tested the functional roles of the FC in a visual contextual memory (VCM) task, which requires intact DG function in rats (Ahn and Lee, 2014; Lee and Lee, 2020). For this purpose, we developed an FC-lesion model using colchicine, which is known to selectively eliminate the DG, leaving other subregions largely unaffected (Walsh et al., 1986). We successfully ablated the FC using colchicine (Fig. 3a; Fig. S4 and S5a; Table S3), leaving the adjacent CA1 and subiculum largely intact (Fig. S5b), presumably because of the similar cell type (i.e., granule cells) found in both DG and FC.
An analysis of dentate gyrus function (an update)
2018, Behavioural Brain ResearchCitation Excerpt :Remembering a specific location in, for example, an eight-arm maze or a water maze may be influenced by the degree of overlap among critical distal spatial cues. dDG-lesioned rats demonstrate deficits similar to complete hippocampal lesions when tested on a working memory version of the radial eight-arm maze [14–17]. In addition, rats with dDG lesions also showed deficits comparable to rats with complete hippocampal lesions when tested on the Morris water maze task if the start location was varied on each trial [18–21].
Mature granule cells of the dentate gyrus-Passive bystanders or principal performers in hippocampal function?
2016, Neuroscience and Biobehavioral ReviewsCitation Excerpt :However, the exact nature of its role is still a matter of debate (Treves et al., 2008). Lesions to the dentate profoundly affect associative and spatial learning (Lee and Kesner, 2004; Nanry et al., 1989; Sutherland et al., 1983; Walsh et al., 1986) and the optogenetic re-activation of granule cells that were active during contextual fear conditioning evokes the stored memory, suggesting that they are indeed part of an engram formed (Liu et al., 2012; Ramirez et al., 2013). Early modeling work of hippocampal circuitry (Marr, 1971) proposed that the dentate gyrus is a key structure for pattern separation, the capacity to discriminate among similar events.
A computational theory of hippocampal function, and tests of the theory: New developments
2015, Neuroscience and Biobehavioral ReviewsAn analysis of the dentate gyrus function
2013, Behavioural Brain ResearchCitation Excerpt :Remembering a specific location in, for example, an eight-arm maze, a water maze, or a spatial context in fear conditioning may be influenced by the degree of overlap among critical distal spatial cues. dDG-lesioned rats demonstrate deficits similar to complete hippocampal lesions when tested on a working memory version of the radial eight-arm maze [18–21]. In addition, rats with dDG lesions also showed deficits comparable to rats with complete hippocampal lesions when tested on the Morris water maze task if the start location was varied on each trial [22–25].
Neurologic and other systemic manifestations in FMF: Published and own experience
2012, Best Practice and Research: Clinical Rheumatology