Differential mechanisms involved in the anticonflict action of benzodiazepines injected into the central amygdala and mammillary body
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Cited by (37)
Re-evaluating the role of the mammillary bodies in memory
2010, NeuropsychologiaInvolvement of the GABA/benzodiazepine receptor in the axiolytic-like effect of nociceptin/orphanin FQ
2008, European Journal of PharmacologyExploratory behaviour of rats in the elevated plus-maze is differentially sensitive to inactivation of the basolateral and central amygdaloid nuclei
2007, Brain Research BulletinCitation Excerpt :The present results show that inactivation of the rat CeA with unilateral injections of muscimol reduced avoidance of open arms in the plus-maze, expressed in terms of the conventional and novel measures of the EPM. The “anxiolytic-like” effects of muscimol in the EPM are in line with the reported anxiolytic effects of BZD receptor agonists in the social interaction and conflict paradigms following intra-CeA infusions [29,33,60,61]. Together, these data support the suggestion that the CeA mediats the exploratory behaviour in the EPM.
The interaction of morphine and γ-aminobutyric acid (GABA)ergic systems in anxiolytic behavior: Using μ-opioid receptor knockout mice
2002, Brain Research BulletinCitation Excerpt :In contrast, morphine did not affect [3H]muscimol binding in any brain area examined in MOR-knockout mice. The enhanced binding in the amygadala is particularly of interest because it has been shown to be the main site of action for the anxiolitic effect of benzodiazepine in conflict-based behavioral assays, such as elevated plus-maze [7]. These data suggest a pathological pathway, initiated by MOR deficit, leading to alteration in the GABAA receptor, which in turn results in changes in benzodiazepine-sensitivity and anxiety.
Regulation of benzodiazepine receptor binding and GABA<inf>A</inf> subunit mRNA expression by punishment and acute alprazolam administration
2000, Brain ResearchCitation Excerpt :Increases in punished responding can also be obtained in humans [1], allowing for follow-up studies when appropriate methods are developed. A number of studies in animals have shown that direct injections of BZs or GABAA receptor agonists into limbic sites can increase punished responding [17,30,33]. In addition, intra-amygdala injections of the BZ antagonist Ro 15-1788 can block BZ-induced increases in punished responding [34].
Differential expression of EGR-1 mRNA in the amygdala following diazepam in contextual fear conditioning
2000, Brain ResearchCitation Excerpt :Most studies have also demonstrated that the central nucleus of the amygdala (CeA) is not a site of anxiolytic or amnesic action of benzodiazepines [9, 58, 62, 67]. However, several studies have found benzodiazepines to act anxiolytically in the CeA [26, 61]. Anatomically, GABA is found in non-pyramidal neurons in the lateral, basolateral, and central nuclei of the amygdala [37, 64, 65], with higher levels in the central nucleus [36, 37].
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Present address: Department of Biodynamics, School of Medicine, Fukuoka University, Fukuoka 814-01, Japan.