Aromaticl-amino acid decar☐ylase-immunoreactive neurons in and around the cerebrospinal fluid-contacting neurons of the central canal do not contain dopamine or serotonin in the mouse and rat spinal cord
Reference (37)
- et al.
5-Hydroxytryptophan decar☐ylase: preparation and properties
J. Biol. Chem.
(1954) - et al.
First demonstration of highly specific and sensitive antibodies against dopamine
Brain Research
(1984) - et al.
Simple purification of aromaticl-amino acid decar☐ylase from human pheochromocytoma using high-performance liquid chromatography
Anal. Biochem.
(1985) - et al.
Use of high concentrations of glutaraldehyde for immunocytochemistry of transmitter-synthesizing enzymes in the central nervous system
Neuroscience
(1986) - et al.
Morphological and histochemical characterization of three types of dopamine-containing neurons in primary cultures of mouse and rat spinal cord
Brain Research
(1986) - et al.
Effects of repeated injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal tyrosine hydroxylase activity in vitro and tyrosine hydroxylase content
Neurosci. Research
(1987) - et al.
Aromatic-l-aminoacid decar☐ylase-immunoreactive cerebrospinal fluid-contacting neurons do not contain dopamine and serotonin in the mouse and rat spinal central canal
Neurosci. Res.
(1988) - et al.
An immunohistochemical study of methione-enkephalin-Arg6-Gly7-Leu8-like immunoreactivity-containing liquor-contacting neurons (LCNs) in the rat spinal cord
Brain Research
(1986) - et al.
Origin and termination of the diencephalo-spinal dopamine system in the rat
Brain Res. Bull.
(1982) - et al.
Quantitative localization of biogenic amines in the spinal cord
Brain Research
(1975)
Dopamine-containing systems in the CNS
Cellular localization of monoamines in the spinal cord
Acta Physiol. Scand.
Monoclonal antibodies against glutaraldehyde-conjugated dopamine
J. Neurochem.
Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of bulbospinal neuron systems
Acta Physiol. Scand.
Immunohistochemical demonstration of catecholaminergic cell bodies in the spinal cord of the rat
Histochemistry
Central catecholamine neurons as revealed by immunohistochemistry with special reference to adrenaline neurons
Some neurons of the rat central nervous system contain aromatic-l-amino acid decar☐ylase but not monoamines
Science
Immunocytochemical localization of aromatic-l-aminoacid decar☐ylase
Cited by (103)
Trace Amines as Intrinsic Monoaminergic Modulators of Spinal Cord Functional Systems
2016, Trace Amines and Neurological Disorders: Potential Mechanisms and Risk FactorsRegulation of the dopaminergic system in a murine model of aromatic l-amino acid decarboxylase deficiency
2013, Neurobiology of DiseaseCitation Excerpt :Coronal sections (40 μm in thickness) were cut on a cryostat and collected in PBS. IHC was performed by incubation overnight with TH (1:50,000) (Nagatsu et al., 1979) or AADC (1:20,000) antibodies (Nagatsu et al., 1988). The slides were washed, incubated for 2 h with a biotinylated anti-rabbit IgG secondary antibody (1:200, Vector Laboratories, Burlingame, CA, USA), and visualized using the VECTASTAIN Elite ABC Kit and Peroxidase Substrate DAB Kit (both from Vector Laboratories, Burlingame, CA, USA).
Aromatic l-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla
2009, Journal of Chemical NeuroanatomyLocalization of l-DOPA uptake and decarboxylating neuronal structures in the cat brain using dopamine immunohistochemistry
2007, Brain ResearchCitation Excerpt :For this reason, the site of the uptake and decarboxylation has been speculated to be in AADC-containing neuronal structures. AADC-immunoreactive (AADC-ir) neurons are shown to be widely distributed not only in catecholaminergic (CA) and serotonergic (5-HT) cell regions (Hökfelt et al., 1973), but also in non-aminergic regions in the rat, cat and human brain (Jaeger et al., 1983a,b, 1984a,b; Nagatsu et al., 1988; Kitahama et al., 1988, 1990b, 1998; Ikemoto et al., 1997). Jaeger et al. (1983a,b) found several groups of AADC neurons in the rat brain, containing neither 5-HT, nor monoamine biosynthetic enzymes such as Tryptophan Hydroxylase (TPOH) and/or Tyrosine Hydroxylase (TH).
Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
2023, Nature Reviews Neuroscience