Research reportEvidence for the presence of two types of potassium channels in the rat optic nerve
References (41)
- et al.
Interactions of barium ions with potassium channels in squid giant axons
Biophys. J.
(1980) - et al.
Rat optic nerve: electrophysiological, pharmacological and anatomical studies during development
Dev. Brain Res.
(1982) - et al.
Functional differences between 4-aminopyridine and tetraethylammonium-sensitive potassium channels in myelinated axons
Neurosci. Lett.
(1987) - et al.
Mammalian optic nerve fibers display two pharmacologically distinct potassium channels
Brain Research
(1986) - et al.
Loss of axons from the optic nerve of the rat during early postnatal development
Dev. Brain Res.
(1982) - et al.
Effects of 4-aminopyridine on rapidly and slowly conducting fibers of rat corpus callosum
Exp. Neurol.
(1983) - et al.
4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve
Brain Research
(1985) - et al.
M-currents and other potassium currents in bullfrog sympathetic neurones
J. Physiol. (London)
(1982) - et al.
Voltage-dependent currents of vertebrate neurons and their role in membrane excitability
Adv. Neurol.
(1986) - et al.
Function and distribution of three types of rectifying channel in rat spinal root myelinated axons
J. Physiol. (London)
(1987)
Application of the sucrose-gap method to determine the ionic basis of the membrane potential of smooth muscle
J. Physiol. (London)
The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibers
J. Physiol. (London)
Potential clamp analysis of membrane currents in rat myelinated nerve fibers
J. Physiol. (London)
Electrical properties of isolated demyelinated rat nerve fibres
Acta Physiol. Scand.
Potassium channels in nodal and internodal axonal membranes of mammalian myelinated fibres
Nature (London)
Evidence for the presence of potassium channels in the paranodal region of acutely demyelinated mammalian single nerve fibres
J. Physiol. (London)
Evidence for the presence of potassium channels in the internode of frog myelinated nerve fibres
J. Physiol. (London)
On the physiological role of internodal potassium channels and the security of conduction in myelinated nerve fibres
A quantitative description of membrane currents in rabbit myelinated nerve
J. Physiol. (London)
Voltage clamp studies of a transient outward membrane current in gastropod neural somata
J. Physiol. (London)
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Potential therapeutic mechanism of K<sup>+</sup> channel block for MS
2013, Multiple Sclerosis and Related DisordersCitation Excerpt :Nevertheless, a 4-AP sensitivity remains, even when myelination is complete, that is not accounted for by a different 4-AP sensitive K+ channel, also expressed at nodes in central axons, KV3.1b (Devaux et al., 2003), and this finding remains unexplained. There is functional evidence for kinetically slow K+ channel expression in mature optic nerve axons, similar to those found in the periphery (i.e. GKs), and these channels are responsible for post-activity hyperpolarization (Gordon et al., 1988; Eng et al., 1988). Because the channels are accessible to TEA ions, they are thought to have a nodal expression pattern, and correspond well with the localization of KCNQ2/KCNQ3, visualized by selective fluorescent antibodies in spinal cord sections (Devaux et al., 2004), Fig. 4, right-hand panel.
In vitro and intrathecal siRNA mediated K <inf>V</inf>1.1 knock-down in primary sensory neurons
2011, Molecular and Cellular NeuroscienceCitation Excerpt :Agents that block voltage-gated K+ (KV) channels in axons have proved very useful in elucidating axonal physiology, for example providing functional evidence regarding the non-homogeneous distribution of different channel sub-types in myelinated nerve (e.g. Bostock et al., 1981; Baker et al., 1987; Gordon et al., 1988).
Beyond faithful conduction: Short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon
2011, Progress in NeurobiologyCitation Excerpt :However, fast potassium channels contribute to spike repolarization in peripheral rat and lizard axons, as specific blockers increase spike duration (Baker et al., 1987; David et al., 1995; Eng et al., 1988; Kocsis et al., 1987). Optical nerve axons and other central axons also show a distinct increase in spike duration when Kv1 channels are blocked (Geiger and Jonas, 2000; Gordon et al., 1988; Shu et al., 2007b). Because some of these channels produce inactivating A-type or D-type currents, their contribution to repolarization and re-excitation changes during repetitive activity.
A model of the mammalian optic nerve fibre based on experimental data
2006, Vision ResearchCitation Excerpt :The spike was followed by a small DAP of 23 ms and a AHP larger than 250 ms 0 (Fig. 5B). This model matches quite well the temporal course of the recorded single fibre action potential (Gordon et al., 1988). When IA was present, small post-spike fluctuations occurred but remained marginal (about three times smaller than when IA = 0).
The optic nerve: A model for axon-glial interactions
2005, Journal of Pharmacological and Toxicological Methods