Research reportEvidence that activation of GABA receptors in the substantia nigra suppresses spontaneous spike-and-wave discharges in the rat
References (46)
- et al.
Current views of the pathobiochemistry of epilepsy
Mol. Aspects Med.
(1987) - et al.
Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the rat
Brain Research
(1971) Central GABAergic systems and feeding behavior
Neurochem. Int.
(1981)- et al.
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist
Physiol. Behav.
(1983) - et al.
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA-agonist or antagonist
Physiol. Behav.
(1985) - et al.
Intranigral muscimol attenuates electrographic signs of seizure activity induced by intravenous bicuculline in rats
Eur. J. Pharmacol.
(1986) - et al.
Intranigral muscimol suppresses ethanol withdrawal seizures
Brain Research
(1984) - et al.
Paradoxical GABA excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons
Eur. J. Pharmacol.
(1979) The epileptic nature of rodent electrocortical polyspiking is still unproven
Exp. Neurol.
(1985)Effects of systemically applied GABA-agonists and antagonists on wave-spike ECoG activity in rat
Neuropharmacology
(1979)
Abortive amygdaloid-kindled seizures following microinjection of γ-vinyl-GABA in the vicinity of substantia nigra in rats
Neurosci. Lett.
Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs
Neuropharmacology
Effect of microinjections of γ-vinyl GABA or isoniazid into substantia nigra on the development of amydala-kindling in rats
Exp. Neurol.
Evidence that substantia nigra is crucial to neural network of kindled seizures
Eur. J. Pharmacol.
Effects of drugs affecting noradrenergic neurotransmission in rats with spontaneous petit mal-like seizures
Eur. J. Pharmacol.
Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures
Brain Research
Nigral muscimol infusions facilitate the development of seizures in immature rats
Dev. Brain Res.
Differential decrease of GABA in the substantia nigra and other discrete regions of the rabbit brain during the preictal period of methoxypyridoxine-induced seizures
Brain Research
Susceptibility to seizures produced by pilocarpine in rats after microinjection of isoniazid or γ-vinyl-GABA into the substantia nigra
Brain Research
Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy
Neurosci. Lett.
Spontaneous spike and wave discharges in thalamus and cortex in a rat model of genetic petit mal-like seizures
Exp. Neurol.
Pyridazinyl-GABA derivatives: a new class of synthetic GABAA antagonists
Trends Pharmacol. Sci.
GABA-agonists and audiogenic seizures
Neurosci. Lett.
Cited by (74)
H1 histamine receptor densities are increased in brain regions of rats with genetically generalized epilepsies
2016, Epilepsy ResearchCitation Excerpt :A specific absence epilepsy effect was a decrease in the compact part of substantia nigra. A role of the substantia nigra is well known and there is evidence that activation of the GABA receptors in the substantia nigra disinhibits thalamo-cortical neurons and suppresses SWDs in GAERS (Depaulis et al., 1988). Mepyramine, an H1 histamine receptor antagonist, was shown to excite GABAergic neurons in the substantia nigra (Korotkova et al., 2002).
Neural adaptation to responsive stimulation: A comparison of auditory and deep brain stimulation in a rat model of absence epilepsy
2013, Brain StimulationCitation Excerpt :In this model, spontaneous generalized non-convulsive seizures characterized by spike-and-wave discharges (SWDs) on the electroencephalogram (EEG) are regularly recorded with a great stability over time [16,17]. We targeted the substantia nigra pars reticulata (SNr) because it was shown that inhibition of this structure has potent anti-epileptic effects in different animal models of epilepsy [18,19], and in the GAERS in particular [20–25]. Recently, we have shown that short-term SNr-DBS very reliably interrupts SWDs in this model when applied at seizure onset, whereas continuous stimulations have limited effects [26].
Lack of effect of intranigral transplants of a GABAergic cell line on absence seizures
2010, Epilepsy and BehaviorCitation Excerpt :Intranigral transplants had no adverse effects on spontaneous locomotor activity, motor coordination, or the general condition of the animals. In this study the substantia nigra was selected as the target for transplantation based on the positive results previously observed in the GAERS model, as well as in models of motor seizures after intranigral GABA agonist administration [24–26] and after GABAergic transplants [12–15,17,27–29]. Kokaia et al. [12] observed a reduction in generalized seizures in rats previously kindled in the amygdala when GABA-releasing polymer matrices were implanted bilaterally and dorsal to the substantia nigra.
Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures
2008, Behavioural Brain ResearchTemporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats
2007, Epilepsy ResearchCitation Excerpt :1) Endogenous GABA concentrations were decreased in amygdala kindled seizures (Loscher and Schwark, 1987). ( 2) Microinjection of GABA and its agonists into the SNr blocked the seizure induced by chemical stimulation (Iadarola and Gale, 1981; Zhang et al., 1989), kindling (Loscher et al., 1987; McNamara et al., 1984), electroshock (Mirski et al., 1986), audiogenic stimulation (Gonzalez and Hettinger, 1984) and genetic manipulations (Depaulis et al., 1988). ( 3) Deep brain stimulation (DBS) of the SNr, presumably via local inhibition, can block amygdala kindled (Morimoto and Goddard, 1987; Shi et al., 2006) and drug induced seizures (Velisek et al., 2002).
Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat
2006, Behavioural Brain Research