Somatostatin presynaptically inhibits transmitter release in feline parasympathetic ganglia

doi:10.1016/0006-8993(89)90940-2

Brain Research

Volume 487, Issue 1, 15 May 1989, Pages 62-68

https://doi.org/10.1016/0006-8993(89)90940-2 Get rights and content

Abstract

Intracellular recordings were made from neurons in cat parasympathetic ciliary ganglia in vitro. Somatostatin (30 nM-3 μM) reduced the amplitude of excitatory postsynaptic potentials (EPSPs), whereas the peptide did not affect acetylcholine (ACh)-induced depolarizations. Thus somatostatin depressed the EPSPs without changing the postsynaptic sensitivity to ACh. The inhibitory action of somatostatin on the EPSPs was passed off even in the presence of the peptide at concentrations higher than 100 nM. When paired stimuli at an interval of 50 ms were applied to preganglionic nerves, the second EPSP was facilitated, being larger in amplitude than the first one; this facilitation was reversibly inhibited in the presence of the peptide. Somatostatin reversibly reduced the frequency of spontaneous EPSPs without appreciably changing their mean amplitude. All of these results indicate that somatostatin may presynaptically reduce the amount of ACh released. The mechanism underlying this action was discussed.

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Somatostatin presynaptically inhibits transmitter release in feline parasympathetic ganglia

Abstract

Neurosci. Lett.

Brain Research

Comp. Biochem. Physiology

TINS

Brain Research

Brain Research

Brain Research

Dual effect of external calcium on the frequency of miniature synaptic potentials in frog sympathetic ganglion cells

Pflu¨gers Arch.

Inhibition of growth hormone secretion in the rat by synthetic somatostatin

Endocrinology

Is somatostatin an excitatory transmitter in the hippocampus?

Nature (Lond.)

Action of somatostatin on excitatory nerves in the intestine

Eur. J. Pharmacol.

Somatostatin selectively inhibits noradrenaline release from hypothalamic neurones

Nature (Lond.)

Somatostatin inhibits the release of acetylcholine-induced electrically in the myenteric plexus

Endocrinology

Calcium-dependent after-potentials in visceral afferent neurones of the rabbit

J. Physiol. (Lond.)

Peptidergic neurones

Nature (Lond.)

Electrophysiological Analysis of Synaptic Transmission