Elsevier

Brain Research

Volume 516, Issue 2, 21 May 1990, Pages 322-325
Brain Research

Glutamate uptake in mammalian retinal glia is voltage- and potassium-dependent

https://doi.org/10.1016/0006-8993(90)90935-5Get rights and content

Abstract

Glutamate evokes an inward membrane current in glial cells from the rabbit retina, by activating high-affinity glutamate uptake. Uptake is strongly inhibited by depolarization. It is also inhibited by removing extracellular sodium or intracellular potassium and by raising the extracellular potassium concentration, suggesting that the uptake carrier transports sodium ions into and potassium ions out of the cell. The voltage- and potassium-dependence of glutamate uptake may have clinical implications: during anoxia, when [K+]0 rises, uptake will be inhibited and the extracellular glutamate concentration may then rise to neurotoxic levels.

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