Elsevier

Brain Research

Volume 520, Issues 1–2, 18 June 1990, Pages 324-329
Brain Research

Intraneuronal laminin-like immunoreactivity in the human central nervous system

https://doi.org/10.1016/0006-8993(90)91723-TGet rights and content

Abstract

Because laminin possesses potent neurotrophic activity, laminin-like immunoreactivity was investigated in formalin-fixed human brains, using affinity-purified anti-human placental laminin rabbit serum. Distinct laminin-like immunoreactivity was observed in neuronal soma of certain nuclear groups, and a 180-kDa band was noted in an immunoblot study of the supernatant of brain homogenate. These observations imply that many but not all central neurons have laminin-like immunoreactive molecules. Their functional role, however, remains to be clarified.

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