Bombesin, neuromedin C and neuromedin B given intrathecally facilitate the tail flick reflex in the rat
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Neural processing of itch
2013, NeuroscienceCitation Excerpt :Neuromedin B is a member of the mammalian bombesin family of peptides along with GRP, and is another candidate as a neuropeptide transmitter in spinal itch transmission. Intrathecal or intracerebroventricular administration of neuromedin B elicited marked scratching (Van Wimersma and Maigret, 1991; Cridland and Henry, 1992; Su and Ko, 2011), while intrathecal administration of neuromedin B produced a transient decrease followed by a delayed increase to above baseline in tail flick latency (Cridland and Henry, 1992). Neurotoxic ablation of neuromedin B receptor-expressing neurons in the superficial dorsal horn did not affect histamine H1 receptor agonist-evoked scratching, but reduced noxious heat-evoked behavioral responses (Mishra et al., 2012), implying a role for neuromedin B in thermal pain.
Inhibition by the chromaffin cell-derived peptide serine-histogranin in the rat's dorsal horn
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2003, European Journal of PharmacologyBombesin and its family of peptides: Prospects for the treatment of obesity
2002, European Journal of PharmacologyTyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368
2001, Journal of Biological ChemistryNonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells
2000, European Journal of Pharmacology