Elsevier

Brain Research

Volume 596, Issues 1–2, 20 November 1992, Pages 325-329
Brain Research

Short communication
Sensitivity of transient outward rectification to ion channel blocking agents in guinea-pig substantia nigra pars compacta neurones in vitro

https://doi.org/10.1016/0006-8993(92)91566-WGet rights and content

Abstract

The sensitivity of a transient outward rectifier in guinea-pig substantia nigra pars compacta (SNC) neurones in vitro was tested to a variety of ion channel blocking agents. This rectification was not blocked by TEA (10 mM), 4-aminopyridine (4-AP) (5 mM), apamin (0.2–1 μM) or Cd2+ ions (200 μM). Cs+ ions (5 mM) blocked the inward ‘anomalous’ rectifier but had no effect on the transient outward rectification. However, replacing Ca2+ ions in the bath perfusate by Ba2+ blocked the transient outward but not the inward rectifier. It is suggested that an atypical barium-sensitive conductance is responsible for the transient outward rectification of these neurones.

References (29)

  • P.D. Shepard et al.

    Effects of apamin on the discharge properties of dopamine-containing neurons in vitro

    Brain Res.

    (1988)
  • M.B. Szente et al.

    Intracellular injection of apamin reduces a slow potassium current mediating afterhyperpolarizations and IPSPs in neocortical neurons of cats

    Brain Res.

    (1988)
  • A.L. Blatz et al.

    Single apamin-blocked Ca-activated K+ channelsof small conductance in cultured rat skeletal muscle

    Nature

    (1986)
  • L.A. Chiodo et al.

    Mesencephalic dopamine-containing neurons in culture: morphological and electrophysiological characterization

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