Widespread expression of gephyrin, a putative glycine receptor-tubulin linker protein, in rat brain
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Artemisinins and their impact on inhibitory neurotransmission
2021, Current Opinion in PharmacologyCitation Excerpt :Here, we review the structures of these two mammalian targets in complex with artesunate and discuss how these drugs affect inhibitory neurotransmission. Gephyrin anchors GABA type A receptors (GABAARs) and glycine receptors (GlyRs) to inhibitory postsynaptic densities (iPSDs) in apposition to presynaptic terminals [26–29]. These pentameric ligand-gated ion channels constitute the primary determinants of fast synaptic inhibition in the central nervous system [32,33].
The α3 subunit of GABAA receptors promotes formation of inhibitory synapses in the absence of collybistin
2021, Journal of Biological ChemistryVariable colocalisation of GABA <inf>A</inf> receptor subunits and glycine receptors on neurons in the human hypoglossal nucleus
2019, Journal of Chemical NeuroanatomyFunctional architecture of the retina: Development and disease
2014, Progress in Retinal and Eye ResearchCitation Excerpt :Indeed, rat OFF-bipolar cell terminals express GlyRα1 but not gephyrin (Sassoe-Pognetto et al., 1994). Thus, unlike GlyRs in the rest of the central nervous system (Kirsch and Betz, 1993), GlyRα1 synapses on bipolar cell terminals might recruit a gephyrin-independent mechanism for clustering or express a splice variant of gephyrin which is not recognized by the antibody. In summary, a myriad of inhibitory synapse types wire retinal processes into functionally discrete circuits in the IPL.
Inhibitory neurotransmission in animal models of tinnitus: Maladaptive plasticity
2011, Hearing ResearchCitation Excerpt :Collectively, these results suggest that peripheral auditory deafferentation results in long-term deficiencies in glycinergic synaptic inhibition in DCN compared with normal adults. To support the GlyR findings delineated above, Wang et al. (2009b) examined gephyrin, a peripheral membrane protein found at the cytoplasmic face of glycinergic synapses and plays a crucial role in the postsynaptic clustering of GlyRs (Triller et al., 1985; Kirsch and Betz, 1993). A number of studies demonstrate that gephyrin is not only used for anchoring receptors to the membrane but is also involved in antero- and retro-grade intracellular trafficking of GlyR complexes (Maas et al., 2006; Kneussel and Loebrich, 2007; Fritschy et al., 2008).
Differential expression of glycine receptor subunits in the rat basolateral and central amygdala
2010, Neuroscience Letters