Interleukin-1β inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat
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Stress and the Reproductive System
2015, Knobil and Neill's Physiology of Reproduction: Two-Volume SetAttractiveness of illness-associated odorant cues in female rats is modulated by ovarian hormones, but not associated with pro-inflammatory cytokine levels
2012, Brain, Behavior, and ImmunityCitation Excerpt :Ovarian activity is typically suppressed by immune challenges. More specifically, ovulation was inhibited and estrogen levels were decreased by LPS administration (Rivest and Rivier, 1993; Nappi and Rivest, 1997). The goal of the following series of experiments, therefore, was to determine whether the reduced attractiveness of female odor in response to immune activation occurs as a result of inflammatory cytokines or due to the reduction of ovarian hormone secretion produced by those inflammatory cascades.
Stress and Reproduction in Mammals
2011, Hormones and Reproduction of Vertebrates - Volume 5Stress and Reproduction in Mammals
2010, Hormones and Reproduction of Vertebrates, Volume 5: MammalsNeuroendocrine regulation of GnRH release and expression of GnRH and GnRH receptor genes in the hypothalamus-pituitary unit in different physiological states
2010, Reproductive BiologyCitation Excerpt :It is worth noting that different kinds of stress may exert a specific effect on hypothalamic-pituitary-ovarian activity. For example, endogenous CRH participates in the suppression of the hypothalamic-pituitary-ovarian axis activity during some challenges, such as footshocks [160], fasting [114] and lactation [204] but not in others, such as immune activation [15, 157]. These observations suggest that different stressors may act differently on the hypothalamic stimulatory and/or inhibitory systems involved in the control of GnRH cell activities; the final effect of stress on GnRH release is determined by the net results of these systems.
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C. Rivier, Clayton Foundation Labs., The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Fax: (1) (619) 552-1546.