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Localization of the cerebellar cortical zone mediating acquisition of eyeblink conditioning in rats
2014, Neurobiology of Learning and MemoryCitation Excerpt :Retention of eyeblink conditioning was partially impaired by infusions of muscimol into the base of the primary fissure but not by infusions into neighboring lobules. Previous studies of the effects of post-acquisition lesions or inactivation of the cerebellar cortex on eyeblink conditioning in rabbits have found either no impairment or a severe impairment in retention (Attwell, Rahman, Ivarsson, & Yeo, 1999; Harvey, Welsh, Yeo, & Romano, 1993; Lavond et al., 1987; Perrett et al., 1993; Woodruff-Pak, Lavond, Logan, Steinmetz, & Thompson, 1993; Yeo & Hardiman, 1992; Yeo et al., 1985b). In some cases CRs could be re-established with additional training (Harvey et al., 1993; Lavond et al., 1987; Yeo & Hardiman, 1992).
Transsynaptic tracing of conditioned eyeblink circuits in the mouse cerebellum
2012, NeuroscienceCitation Excerpt :Significant controversy exists regarding the location of eyeblink conditioning neurons in the CbCtx. HVI has been strongly implicated in eyeblink conditioning (Berthier and Moore, 1986; Lavond and Steinmetz, 1989; Woodruff-Pak et al., 1993; Gould and Steinmetz, 1994; Hesslow and Ivarsson, 1994; Attwell et al., 1999), but more recent studies have considered the anterior cerebellar lobules for a role in the acquisition or timing of the conditioned eyeblink (Perrett et al., 1993; Mauk and Donegan, 1997; Garcia et al., 1999; Medina et al., 2000; Kalmbach et al., 2010). PRV-infected cells were observed in both HVI and anterior cerebellar lobules, indicating that Purkinje cells in both locations are anatomically connected to and capable of modulating eyelid muscles.
The role of the cerebellum in classical conditioning of discrete behavioral responses
2009, NeuroscienceCitation Excerpt :Any or all of these factors could contribute to differences in results that have been reported concerning the role of lobule HVI in eye-blink conditioning. At this point, this issue has not been satisfactorily resolved even though a number of other studied have been conducted (Gruart and Yeo, 1995; Harvey et al., 1993; Lavond and Steinmetz, 1989; Woodruff-Pak et al., 1993; Yeo and Hardiman, 1992). Several pharmacological agents are available to permanently eliminate neurons in a given brain area (e.g. kainic acid and ibotenic acid) or temporarily inactivate an area (e.g. lidocaine, muscimol, and picrotoxin), and these methods have been used to study the involvement of cerebellar cortex in conditioning.
A neurocomputational model of classical conditioning phenomena: A putative role for the hippocampal region in associative learning
2009, Brain ResearchCitation Excerpt :Initiating conditioned responses was shown to be mediated by cerebellar projection to the red nucleus of the brain stem (Chapman et al., 1990). In one interesting study, Woodruff-Pak et al. (1993) found that inactivating different segments of the cerebellum after learning the eye blink conditioning task does not interfere with performing the task, suggesting that the cerebellum is key for learning processes. Furthermore, patients with essential tremor—who were shown to have loss of cerebellar Purkinje cells—show impairment at learning classical conditioning tasks (Shill, De La Vega et al., 2009).
Cerebellar substrates for error correction in motor conditioning
2001, Neurobiology of Learning and MemoryBrain substrates of classical eyeblink conditioning: A highly localized but also distributed system
2000, Behavioural Brain Research