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Cited by (28)
An allosteric propofol-binding site in kinesin disrupts kinesin-mediated processive movement on microtubules
2018, Journal of Biological ChemistryCitation Excerpt :The human kinesin superfamily includes 45 genes, 38 of which are expressed in brain (5). Three subfamilies of kinesins are predominantly responsible for the fast (∼2–5 μm/s) (6, 7) and slow (∼0.02–0.09 μm/s) (8) transport of cargo to synapses. In contrast, cytoplasmic dynein is the major molecular motor responsible for retrograde transport to the cell body (2, 3, 9, 10).
Axonal transport declines with age in two distinct phases separated by a period of relative stability
2015, Neurobiology of AgingCitation Excerpt :Conventional tracking of radiolabeled cargoes or newer approaches using tetanus neurotoxin (Millecamps and Julien, 2013) do not easily allow this distinction. Video-enhanced imaging provides information on transport rates in individual axons (Viancour and Kreiter, 1993) but does not easily distinguish between different cargoes. Mitochondrial transport declines in individual peripheral nerve axons between 8 and 24 months of age (Gilley et al., 2012), but how much this is representative of other cargoes and other regions of the nervous system, especially in the CNS, remains unknown.
Molecular Signaling. How Do Axons Die?
2011, Advances in GeneticsCitation Excerpt :Remarkably, however, more distal axon regions survive many months without degenerating, indicating that enough material flows through the swellings to support distal axons (Adalbert et al., 2009). Axonal transport falls dramatically with ageing, affecting fast and slow transport of many cargoes both in retrograde and anterograde directions (Castel et al., 1994; Fernandez and Hodges-Savola, 1994; Frolkis et al., 1997; Li et al., 2004; McQuarrie et al., 1989; Tashiro and Komiya, 1994; Viancour and Kreiter, 1993). In rats aged two years, the average velocity of axonal transport is less than half that in young rats and may decline by as much as 71% (Frolkis et al., 1997; Minoshima and Cross, 2008).
Local application of olprinone for promotion of peripheral nerve regeneration
2009, Journal of Orthopaedic Science