μ-Opiate receptor binding is up-regulated in mice selectively bred for high stress-induced analgesia
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Bidirectional selection for high and low stress-induced analgesia affects G-protein activity
2019, NeuropharmacologyCitation Excerpt :Multiple studies in inbred strains delivered evidence that opioid sensitivity was correlated with alterations in opioid receptor expression, density or was linked with the existence of specific quantitative trait locus (QTL) markers (Kest et al., 1998; Krumins et al., 1990) (Belknap et al., 1995; Kozak et al., 1994). Quantitative autoradiographic analysis with [3H] naloxone revealed that the most prominent differences in binding site density between opioid-sensitive HA and opioid-insensitive LA mice were noted in the medial thalamus (Mogil et al., 1994). A similar assessment showed a 2 - fold difference in μ-opioid site densities in the dorsal raphe nucleus in the HAR and LAR mice. (
Stress and Opioid Systems
2017, Hormones, Brain and Behavior: Third EditionThe genetics of pain: Implications for evaluation and treatment of spinal disease
2010, Spine JournalCitation Excerpt :Selective breeding using unilateral sciatic and saphenous nerve sectioning to develop high-autotomy and low-autotomy strains of rats has led to the surprising conclusion that only one autosomal recessive genetic locus is responsible for inheritance of this trait [15]. Further examination of these strains has revealed significant interstrain differences in heat and mechanical pain sensitivity as well as increased μ-opiate receptor-binding density in the medial thalamic region of brains of high-autotomy mice [16,17]. Increased levels of μ-receptor messenger RNA (mRNA) have also been identified in the nucleus raphe magnus of high-autotomy mice [18].
Opposite effects of alcohol in regulating stress-induced changes in body weight between the two mouse lines with enhanced or low opioid system activity
2010, Physiology and BehaviorCitation Excerpt :HA (high analgesia) and LA (low analgesia) mouse lines selected for high or low swim stress-induced analgesia (SSIA) differ substantially in nociceptive responses both before and after stress [19]. Compared to LA mice, HA mice exhibit an upregulation of opioid receptor system function, are more sensitive to morphine, and display a higher analgesic response to µ, δ and κ receptors selective agonists [6,7,13,16]. Further studies with the HA/LA mouse model revealed that analgesia induced by the swim stress correlates with changes in whole body metabolism during swimming [9,10].
Stress-induced analgesia
2009, Progress in Neurobiology