Research reportMicrozonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR 2/3 and GluR 5/6/7 in the human epileptogenic neocortex
References (40)
Glutamate neurotoxicity and diseases of the nervous system
Neuron
(1988)- et al.
The pyramidal neuron of the cerebral cortex: Morphological and chemical characteristics of the synaptic inputs
Prog. Neurobiol.
(1992) - et al.
Determinats of the calcium permation of ligand-gated cation chanels
Curr. Op. Cell. Biol.
(1992) Horizontal integration and cortical dynamics
Neuron
(1992)- et al.
Excitatory synaptic transmission mediated by NMDA and non-NMDA receptors in the superficial/middle layers of the epileptogenic human neocortex maintained in vitro
Neurosci. Lett.
(1992) - et al.
Kainate and quisquilate receptor autoradiography in rat brain after angular bundle kindling
Neuroscience
(1990) - et al.
Alterations of the Glu-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia
Neuroscience
(1993) - et al.
Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies
J. Biol. Chem.
(1992) - et al.
Electrophysiological properties and synaptic responses in the deep layers of the human epileptogenic neocortex in vitro
J. Neurophysiol.
(1989) - et al.
Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit
Neuron
(1992)
Regulation of AMPA-selective subunits of the glutamate receptor in monkey striate cortex and LGN
Neurosci. Abstr.
Horizontal spread of synchronized activity in neocortex, and its control by GABA-mediated inhibition
J. Neurophysiol.
Periodicity and directionality in the propagation of epileptiform discharges across neocortex
J. Neurophysiol.
Neocortical neuronal diversity: chemical heterogeneity revealed by colocalization studies of classic neurotransmitters, neuropeptides, calcium binding proteins and cell surface molecules
Cerebral Cortex
Long-range focal collateralization of axons arising from corticocortical cells in monkey sensory-motor cortex
J. Neurosci.
Selective changes in the microorganization of the human epileptogenic neocortex revealed by parvalbumin immunoreactivity
Cerebral Cortex
Cellular mechanisms of epilepsy: a status report
Science
Excitatory amino acid receptors in epilepsy
Trends Pharm. Sci.
Mechanisms of neocortical epileptogenesis in vitro
J. Neurophysiol.
Metabolic manipulation of neural tissue to counter the hypersynchronous excitation of migraine and epilepsy
Neurochem. Res.
Cited by (41)
Inhibition and oscillations in the human brain tissue in vitro
2019, Neurobiology of DiseaseCitation Excerpt :Thus, different human interneuronal subtypes may play specific roles in generating and maintaining neocortical gamma oscillations. Subtle regional differences in the organization of local GABAergic and glutamatergic microcircuits may operate in the diseased human brain (Alonso-Nanclares et al., 2005; DeFelipe et al., 1994, 1993; Foehring et al., 1991; Menendez de la Prida et al., 2002). A repertoire of fast events including spindles (7–14 Hz), gamma bouts and ripples could naturally couple to slow neocortical oscillations (Csercsa et al., 2010), but depending on the excitability level and the integrity of GABAergic mechanisms these events could reflect abnormal synchronous firing in epileptogenic territories (Alvarado-Rojas et al., 2015; Kohling et al., 1999).
Aberrant glutamate receptor 5 expression in temporal lobe epilepsy lesions
2010, Brain ResearchCitation Excerpt :We demonstrated that GluR5 mRNA and protein levels were upregulated in the hippocampus of patients with TLE compared to controls, whereas GluR5 expression in the neocortex of TLE patients did not differ from that of controls. The latter result is similar to the findings of DeFelipe (DeFelipe et al., 1994). Taken together, these data suggest that GluR5 upregulation in the hippocampus, but not in the neocortex, is involved in the pathological mechanism of pharmacoresistant TLE in humans.