Research reportThe evolution of a rat model of chronic spontaneous limbic seizures
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2017, Neurobiology of DiseaseCitation Excerpt :In brief, animals were stimulated for 90 min with 10-s trains of 50 Hz, 1 ms biphasic square waves with a maximum intensity of 400 μA peak to peak delivered every 11 s. Following the induction of and recovery from limbic status epilepticus, rats were placed in standard laboratory housing. Three months after the induction of status epilepticus, animals were evaluated for the presence and frequency of spontaneous temporal lobe seizures (Bertram and Cornett, 1994). During the monitoring phase, rats were placed in specially designed cages, which allowed full mobility of the animals, good visualization for video monitoring, and a stable recording environment.
Post-Status Epilepticus Models: Systemic Kainic Acid
2017, Models of Seizures and Epilepsy: Second Edition
Copyright © 1994 Published by Elsevier B.V.