Footshock facilitates the expression of aversively motivated memory in rats given post-training amygdala basolateral complex lesions
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Emotion in action: When emotions meet motor circuits
2023, Neuroscience and Biobehavioral ReviewsOvertraining modifies spatial memory susceptibility to corticosterone administration
2017, Neurobiology of Learning and MemoryCitation Excerpt :By contrast with what happened in trained animals, corticosterone (regardless of the dose administered) did not affect overtrained animals’ performance during the spatial retrieval test, thereby indicating that overtraining makes spatial memory less susceptible to corticosterone’s harmful effects. There is evidence that increased amount of trials during the training of both classically and instrumentally conditioned tasks can prevent the deleterious effect of different experimental manipulations, such as pharmacological treatment (Mesches, Bianchin, & McGaugh, 1996; Prado-Alcalá et al., 1978; Roesler et al., 1999), aging (van Groen, Kadish, & Michael Wyss, 2002), cerebral structure inactivation (Garín-Aguilar, Medina, Quirarte, McGaugh, & Prado-Alcalá, 2014; Prado-Alcalá & Cobos-Zapiaín, 1979) and cerebral lesions (Maren, 1999; Parent, Avila, & McGaugh, 1995; Parent, West, & McGaugh, 1994; Prado-Alcalá, Kaufman, & Moscona, 1980; Prado-Alcalá et al., 1978). Among the many modifications of the memory trace induced by training, it is noteworthy that there have been found changes in MR to GR mRNA ratio due to increase in GR expression in the hippocampus (Lubec & Korz, 2016), and increase of GR immunoreactivity in the prelimbic cortex (Vargas-López & Múnera, 2016); moreover, in both studies there have been found a direct correlation between GR expression in this structures and performance in spatial memory tasks.
Brain sites involved in fear memory reconsolidation and extinction of rodents
2015, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Indeed, the amygdala was demonstrated to be critical for the acquisition, consolidation and expression of cued and contextual fear conditioning. In addition, results obtained by inhibitory avoidance experiments show that this neural structure is also important for this form of fear memory, although in this case it seems to have a modulatory role as amygdala lesions attenuate, but do not block, inhibitory avoidance learning (Parent et al., 1994, 1995; Parent and McGaugh, 1994). The involvement of the amygdala, in particular the basolateral complex (BLA), in the fear memories reconsolidation (Table 1) has been highlighted by means of tetrodotoxin (TTX) or lidocaine functional inactivation, blockers of voltage-dependent sodium channels, thus impeding the initiation and propagation of action potentials.
Interacting brain systems modulate memory consolidation
2012, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The evidence that intra-amygdala infusions of d-amphetamine and other drugs can affect performance on tasks such as these (Packard et al., 1994; Packard and Gabriele, 2009) suggests that the amygdala is a modulatory structure; although it can influence memory, it is not necessary for maintaining or expressing memory. The evidence that memory for the aversive inhibitory avoidance task is not lost when the amygdala is inactivated or lesioned one day to one month after training (Bevilaqua et al., 1997; Izquierdo et al., 1997; Parent et al., 1994, 1995), indicates that the amygdala is not the final storage site for emotionally arousing memories. Packard et al. (1994) found compelling evidence that the amygdala modulates memory storage in efferent brain regions in rats.
Effects of N-methyl-D-aspartate-induced amygdala lesion in rats submitted to the elevated T-maze test of anxiety
2003, Physiology and Behavior