Physiological levels of β-amyloid increase tyrosine phosphorylation and cytosolic calcium
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Targeting Fyn Kinase in Alzheimer's Disease
2018, Biological PsychiatryCitation Excerpt :Prior to this functional association between Aβos and Fyn, there was already emerging evidence linking Fyn to Aβ. Various Aβ preparations were shown to increase tyrosine phosphorylation in vitro (28–30), and histologic analysis of brain sections from patients with AD showed an enhanced Fyn staining pattern in neurons also containing abnormally phosphorylated tau (31). The molecular interaction between Fyn and tau has since been greatly refined.
Tau and src family tyrosine kinases
2005, Biochimica et Biophysica Acta - Molecular Basis of DiseaseActivation of muscarinic receptors inhibits β-amyloid peptide-induced signaling in cortical slices
2003, Journal of Biological ChemistryCitation Excerpt :Therefore, the Aऔ-induced dysfunction of cortical and hippocampal neurons, not their death, may be largely responsible for the impairments in learning and memory associated with AD. Previous studies have found that Aऔ administration induced a marked increase in the tyrosine phosphorylation of multiple proteins in nerve cell lines and cortical cultures (49-51), suggesting that Aऔ has the potential to modulate cellular responses to growth factors and extracellular matrix molecules. In this study, we report a rapid and potent activation of two important serine/threonine kinases, PKC and CaMKII, in response to Aऔ25–35, Aऔ1–42, and Aऔ1–40 in cortical slices.
Factors influencing the processing and function of the amyloid β precursor protein - A potential therapeutic target in Alzheimer's disease?
2000, Pharmacology and Therapeutics