Research reportGlucose enhancement of scopolamine-induced increase of hippocampal high-affinity choline uptake in mice: relation to plasma glucose levels
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Glucose attenuates impairments in memory and CREB activation produced by an α4β2 but not an α7 nicotinic receptor antagonist
2013, NeuropharmacologyCitation Excerpt :Glucose may modulate the activity of α7 receptors by regulating local extracellular choline levels. Previous studies indicate that glucose regulates high-affinity choline uptake and can act synergistically to improve memory when administered together with choline (Kopf et al., 2001; Micheau et al., 1995; Messier et al., 1990). However, the effects of glucose on extracellular choline levels, in the context of memory enhancement, have not been directly investigated.
Glucose increases hippocampal extracellular acetylcholine levels upon activation of septal GABA receptors
2003, Brain ResearchCitation Excerpt :Combined with the present findings, we suggest that glucose reverses the memory-impairing effects of septal GABA receptor activation by increasing ACh function in the hippocampus. Glucose administration enhances memory in its own right and extensive evidence suggests that these facilitatory effects of glucose also likely involve an effect on ACh function in brain regions involved in memory [13,14,18,19,28–30]. As memory deficits and ACh hypofunction are associated with aging and Alzheimer’s disease, the present findings provide a model for studying potential mechanisms and interventions for deficits associated with these disorders.
The cerebral glucose-fatty acid cycle: Evolutionary roots, regulation, and (patho)physiological importance
2002, International Review of Neurobiology