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Chronic blockade of interleukin-1 (IL-1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury
2011, European Journal of PainCitation Excerpt :A growing body of evidence indicates that the pro-inflammatory cytokine interleukin-1 (IL-1) is involved in pain sensation (Watkins and Maier, 2002; Wolf et al., 2003; Shavit et al., 2005; Bessler et al., 2006; Guimaraes et al., 2006), as well as in neuropathic pain (Raghavendra et al., 2002; DeLeo et al., 2004; Wolf et al., 2006; Honore et al., 2006; Ledeboer et al., 2007; McGaraughty et al., 2007; Norman et al., 2009). Numerous reports have shown that peripheral, spinal, or cerebral administration of IL-1β usually produces hyperalgesia and allodynia (Ferreira et al., 1988; Oka et al., 1993; Watkins et al., 1994; Oka et al., 1995; Safieh-Garabedian et al., 1995; Tadano et al., 1999; Reeve et al., 2000; Falchi et al., 2001; Lee et al., 2004), whereas its blockade at the spinal level prevents hyperalgesia induced by various immune challenges (Watkins et al., 1994, 1997; Milligan et al., 2001; Samad et al., 2001). IL-1 may be particularly relevant to neuropathic pain, as peripheral nerve injury triggers an inflammatory response (Rotshenker et al., 1992; DeLeo et al., 1997; Shamash et al., 2002), including activation of spinal cord glia and the secretion of pro-inflammatory cytokines (Clatworthy et al., 1995; Colburn et al., 1999; Raghavendra et al., 2003a,b; DeLeo et al., 2004).
Interleukin-1 signaling modulates stress-induced analgesia
2007, Brain, Behavior, and ImmunityCitation Excerpt :The span of this analgesic response is similar to the SIA found in the present study, which is also short-lived. That IL-1 had no effect on pain sensitivity when administered directly into the paraventricular nucleus (PVN) of the hypothalamus (Oka et al., 1995), suggests that SIA is mediated by a separate mechanism than HPA axis activation. Consistent with these data, i.c.v administration of corticotropin-releasing hormone (CRH) shown to induce many stress-like behaviors, such as increased startle response (Cole and Koob, 1988) and decreased sleeping time (Sherman and Kalin, 1987), but had no effect on pain threshold (Sherman and Kalin, 1987).
Role of substantia innominata in cerebral blood flow autoregulation
2007, Brain ResearchThe differential role of prostaglandin E<inf>2</inf> receptors in the CNS response to systemic immune challenge
2007, Psychoneuroimmunology, Two-Volume Set