Characterization of axonal ultrastructural pathology following experimental spinal cord compression injury
References (57)
An electron-microscopic analysis of axonal alterations following blunt contusion of the spinal cord of the Rhesus monkey (Macaca mulatta)
J. Neurol. Sci.
(1978)- et al.
A neuroanatomical analysis of spinal cord injury in the Rhesus monkey (Macaca mulatta)
J. Neurol. Sci.
(1976) - et al.
Analysis of axon-sheath relations during early Wallerian degeneration
Brain Res.
(1970) - et al.
Ca2+ accumulation in experimental spinal cord trauma
Brain Res.
(1981) - et al.
Preservation of neuronal ultrastructure in hippocampal slices using rapid microwave-enhanced fixation
J. Neurosci. Meth.
(1989) - et al.
Accumulation of axoplasmic organelles in swollen nerve fibers
Brain Res.
(1970) - et al.
Assessment of spinal cord injury by counting corticospinal and rubrospinal neurons
Brain Res.
(1987) - et al.
Peripheral neuropathy with giant axons and cardiomyopathy associated with desmin type intermediate filaments in skeletal muscle
J. Neural. Sci.
(1992) Calcium-induced degeneration of axoplasm in isolated segments of rat peripheral nerve
Brain Res.
(1974)Structural alterations of peripheral nerve induced by the calcium ionophore A23187
Brain Res.
(1977)
Characterization of the calcium-induced distribution of neurofilaments in rat peripheral nerve
Brain Res.
Electron microscopic observations of the delayed effects of spinal cord compression
Exp. Neural.
Ultrastructural concomitants of anoxic injury and early post-anoxic recovery in rat optic nerve
Brain Res.
Extracellular calcium ionic activity in experimental spinal cord contusion
Brain Res.
Spinal cord edema, 5-hydroxytryptamine, lipid peroxidation, and lysosomal enzyme release after acute contusion and compression injury in primates
Cent. Nerd. Syst. Trauma
Axonal calcification in spinal cord injury of humans, monkeys, and cats
J. Neuropath. Exp. Neurol.
Pathology of experimental spinal cord trauma. 11. Ultrastructure of axons and myelin
Lab. Invest.
Spinal cord trauma: in search of the meaning of granular axoplasm and vesicular myelin
J. Neuropath. Exp. Neurol.
Ultrastructural pathology of nerve fibers in calcium-induced myelopathy
J. Neuropath. Exp. Neurol.
Vesiculation of myelin in postmortem autolysis
J. Neuropath. Exp. Neurol.
Ultrastructural pathology of axons and myelin in calcium-induced myelopathy
Neuropath. Exp. Neurol.
Molecular and anatomical correlates of spinal cord injury
Cent. Neru. Syst. Trauma
The effects of spinal cord trauma on myelin
J. Neuropath. Exp. Neurol.
Delayed demyelination and macrophage invasion: A candidate for secondary cell damage in spinal cord injury
Cent. Nerv. Syst. Trauma
Observations on the pathology of human spinal cord injury. A review and classification of 22 new cases with details from a case of chronic cord compression with extensive focal demyelination
Ado. Neurol.
The effect of traumatic brain injury on the visual system: a morphological characterization of reactive axonal change
J. Neurotrauma
Response of lysosomal hydrolases of dog spinal cord and cerebrospinal fluid to experimental trauma
Neurology
Spinal cord injury. Review of basic and applied research
Spine
Cited by (41)
Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis
2019, Journal of Chemical NeuroanatomyCitation Excerpt :In all analyses, p < 0.05 was considered as the level of significance. Thirty nine related articles were included involving 789 experimental animals (Anthes et al., 1995; Arvanian et al., 2009; Bretzner et al., 2008; Busch et al., 2011, 2009; Choo et al., 2008; Darlot et al., 2012; Ek et al., 2010, 2012; Evans et al., 2014; Fehlings and Tator, 1995; Gensel et al., 2015; Gledhill and McDonald, 1977; Guest et al., 1997; Hesp et al., 2015; Horn et al., 2008; Houle and Jin, 2001; Huang et al., 2014; James et al., 2011; Kerschensteiner et al., 2005; Lasiene et al., 2008; Muradov et al., 2013; Nashmi and Fehlings, 2001; Oudega et al., 1999; Pallini et al., 1988; Powers et al., 2012, 2013; Rosenberg and Wrathall, 1997; Seif et al., 2007; Siegenthaler et al., 2007; Stirling et al., 2013, 2004; Tang et al., 2015; Totoiu and Keirstead, 2005; Wang et al., 2012, 2009; Wang et al., 2015; Ward et al., 2014; Wu et al., 2013) (Fig. 1). Twenty nine studies were performed on rats, eight on mice, one on cats, and one on monkeys.
Intracellular calcium release through IP<inf>3</inf>R or RyR contributes to secondary axonal degeneration
2017, Neurobiology of DiseaseCitation Excerpt :In support, acutely following SCI in vivo, sheared or transected dorsal column axons form swollen “terminal clubs” or endbulbs that retract/dieback away from the lesion site over time (Kao et al., 1977; Stirling et al., 2004; Erturk et al., 2007; Hill, 2017). Ultrastructural studies revealed that periaxonal swelling, myelin vesiculation, terminal endbulb formation, and spheroid formation are prominent findings following SCI in vivo (Balentine, 1978; Anthes et al., 1995). Correspondingly, and as shown here in Figs. 1–4, the LiSCI model induces axonal endbulb formation, axonal dieback, periaxonal swelling and separation of myelin, and axonal spheroid formation.
The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury
2017, Experimental NeurologyAn early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease
2015, Neurobiology of DiseaseCitation Excerpt :Even in the absence of spheroids, AVs were observed in axons within the MFB in the transgenic mice (Fig. 7A). In addition to AVs other abnormalities were observed, including enlargement of the periaxonal space (Fig. 7B) and intra-axonal invagination of myelin (Fig. 7B) as described in other forms of axonal injury (Anthes et al., 1995). Axonal pathology may either precede pathology at the level of the neuron soma or occur subsequent to it, as a secondary event.
Buckling behavior of individual and bundled microtubules
2015, Biophysical JournalCitation Excerpt :In addition to normal biological functions, MTs might also experience buckling and breaking in traumatic injuries. Axon compression is a common feature of traumatic injuries (32–35) and therefore axonal MT bundles may experience pathological compressive forces leading to their buckling and breaking. Buckling of MTs has been studied through computational and experimental works in recent years.