Elsevier

Brain Research

Volume 721, Issues 1–2, 20 May 1996, Pages 155-166
Brain Research

The effects of subcortical lesions on evoked potentials and spontaneous high frequency (gamma-band) oscillating potentials in rat auditory cortex

https://doi.org/10.1016/0006-8993(96)00168-0Get rights and content

Abstract

Functional subdivisions of auditory cortex in the rat were identified based on the distribution of temporal components of the mid-latency auditory evoked potential (MAEP) recorded with a multichannel epipial electrode array. Spontaneous data collected from the same location exhibited spindle-shaped bursts of oscillations in the gamma-band (20–40 Hz) whose location and spatial distribution were similar to that of the MAEP complex in that the bursts were localized to primary and secondary auditory cortex, the principle targets of thalamocortical projections. This suggested that the neural generators of these electrophysiological events may be similar. However, ablation of the medial geniculate nucleus (MG) of the thalamus revealed that while this nucleus is required for the generation of MAEPs, it is not required for the generation of spontaneous gamma-band oscillations. Ablation of subcortical cholinergic nuclei revealed that cholinergic input via the thalamus or the basal forebrain is not necessary for the generation of either MAEPs or spontaneous gamma-band oscillations recorded in this study. These results indicated that there may be networks of cells in sensory cortical areas endowed with an intrinsic capacity to oscillate independently of sensory or cholinergic input, but that may be modulated by this input.

References (53)

  • SteriadeM. et al.

    Electrophysiological properties of intralaminar thalamocortical cells discharging rhythmic ( ≈ 40 Hz) spike-bursts at ≈ 1000 Hz during waking and rapid eye movement sleep

    Neuroscience

    (1993)
  • BarthD.S. et al.

    Laminar excitability cycles in neocortex

    J. Neurophysiol.

    (1990)
  • BarthD.S. et al.

    Three dimensional analysis of auditory evoked potentials in rat neocortex

    J. Neurophysiol.

    (1990)
  • BarthD.S. et al.

    The spatiotemporal organization of auditory, visual, and polysensory evoked potentials in rat cortex

    Brain Res.

    (1995)
  • CreutzfeldtO.D. et al.

    Neuronal basis of EEG-waves

  • DiS. et al.

    The functional anatomy of middle latency auditory evoked potentials: Thalamocortical connections

    J. Neurophysiol.

    (1992)
  • EckhomR. et al.

    Coherent oscillations: A mechanism of feature linking in visual cortex?

    Biol. Cybern.

    (1988)
  • EckhornR. et al.

    Stimulus-specific synchronizations in cat visual cortex: multiple microelectrode and correlation studies from several cortical areas

  • EngelA.K. et al.

    Synchronization of oscillatory neuronal responses between striate and extrastriate visual cortical areas of the cat

  • FranowiczM.N. et al.

    A comparison of evoked potentials and high frequency (gamma-band) oscillating potentials in rat auditory cortex

    J. Neurophysiol.

    (1995)
  • GalambosR.

    Tactile and auditory stimuli repeated at high rates (30–50 per sec) produce similar event related potentials

    Ann. N.Y. Acad. Sci.

    (1982)
  • GalambosR.

    A Comparison of Certain Gamma Band (40-Hz) Brain Rhythms in Cat and Man

  • GalambosR. et al.

    A 40-Hz auditory potential recorded from the human scalp

  • GrayC.M. et al.

    Mechanisms Underlying the Generation of Neuronal Oscillations in Cat Visual Cortex

  • GrayC.M. et al.

    Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex

  • GuldinW.O. et al.

    Cortical and thalamic afferent connections of the insular and adjacent cortex of the rat

    J. Comp. Neurol.

    (1983)
  • Cited by (20)

    View all citing articles on Scopus
    View full text