Heat stress reduces glutamate toxicity in cultured neurons without HSP70 expression
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Cited by (11)
Mild heat stress induces hormetic effects in protecting the primary culture of mouse prefrontal cerebrocortical neurons from neuropathological alterations
2018, IBRO ReportsCitation Excerpt :It will substantially contribute to improve the health of general public directly by creating the awareness and indirectly by using the concept of hormesis while framing the government policies related to healthcare sector. Various studies have reported that mild heat stress exerts beneficial effects on the neurons by improving the functional ability, neurite outgrowth, neuroprotection and neuronal survival in various neurodegenerative disorders such as Alzheimer’s disease, Parkinson disease, Huntington’s disease etc. (Snider and Choi, 1996; Mattson and Cheng, 2006; Umschweif et al., 2014). The hormetic effects can be studied as a preconditioning hormesis and a postconditioning hormesis (Calabrese et al., 2007; Calabrese, 2016a, 2016b).
Cycloheximide reduces infarct volume when administered up to 6 h after mild focal ischemia in rats
2001, Brain ResearchCitation Excerpt :Proteins (10 μg) were denatured in Laemmli loading buffer and electrophoresed on a 10% SDS–polyacrylamide gel. Immunoblotting was performed as previously described [60] except that a chemiluminescent detection system was used (SuperSignal ECL, Pierce Chemical Co). Blots were probed with antibody specific for the inducible isoform of HSP70 (SPA-810, StressGen, 1:2000), β-tubulin (YOL1/34, Accurate Chemical Co., 1:1000), prostate apoptotis response gene 4 (PAR4, Santa Cruz R-334, 1:2500), apoptosis linked gene 2 (ALG-2, Transduction Laboratories, 1:1000), and Fas ligand/CD95L (FasL, Transduction Laboratories, 1:2500).
Ischemic 'cross' tolerance in hypoxic ischemia of immature rat brain
1999, Brain Research