Elsevier

Brain Research

Volume 734, Issues 1–2, 23 September 1996, Pages 349-353
Brain Research

Reduction of NaCl increases survival of mammalian spinal neurons subjected to dendrite transection injury

https://doi.org/10.1016/0006-8993(96)00804-9Get rights and content

Abstract

Neurites were transected from spinal neurons in media with normal (125 mM) or reduced NaCI (sucrose substitution). After 12 h the normal ionic environment (conditioned medium with serum) was restored. A one-factor ANOVA comparison found a significant difference in 48 h survival (P = 0.0001). Survival was highest when NaCl was reduced 50% (74% ± 19 vs. 22% ± 19 in normal NaCI). Na+ - and Cl-mediated deterioration may contribute to both gray and white matter injury in CNS trauma.

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