Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system
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Feeding behaviour after injection of α-adrenergic receptor agonists into the median raphe nucleus of food-deprived rats
2012, Physiology and BehaviorCitation Excerpt :The absence of feeding effects after treatment with PHE in the MnR of free-feeding rats could be due to elevated adrenergic inputs on serotonergic neurons [39,48]. It seems that the reduction of an adrenergic inhibitory influence in food-deprived rats allows for α1-adrenergic receptor activation by PHE, resulting in 5-HT release, since facilitatory control of 5-HT release is attributed to α1-adrenoceptors [21,30] situated on MnR serotonergic cell bodies [55]. In agreement with this suggestion, we have recently reported [47] that the blockade of α1-adrenergic receptors within the MnR of free-feeding rats resulted in hyperphagia accompanied by a reduction in the latency to start eating, an increase in feeding duration and an increase in feeding frequency.
Serotonin Interaction with Other Transmitter Systems
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :It is well known that noradrenergic afferents from the LC innervate the DR (Baraban and Aghajanian, 1980; Peyron et al., 1996), which has been corroborated by the presence of noradrenaline and its uptake sites in the DR (Tejani-Butt, 1992; Ordway et al., 1997; Strazielle et al., 1999). Noradrenaline exert a tonic facilitation of serotonergic transmission through (1-adrenoceptors (Baraban and Aghajanian, 1980; Marwaha and Aghajanian, 1982; Vandermaelen and Aghajanian, 1983; Pan et al., 1994; Adell and Artigas, 1999; Bortolozzi and Artigas, 2003; Pudovkina et al., 2003) located in the DRN (Pieribone et al., 1994; Day et al., 1997), possibly in the cell bodies' of serotonergic neurons (Gallager and Aghajanian, 1976a). Consistent with their action on the firing rate of serotonergic neurons, (α1-adrenoceptor antagonists decrease the release of 5-HT in projection areas (Rouquier et al., 1994; Hjorth et al., 1995; de Boer et al., 1996; Pudovkina et al., 2003).
Investigation of the SSRI augmentation properties of 5-HT<inf>2</inf> receptor antagonists using in vivo microdialysis
2006, NeuropharmacologyCitation Excerpt :It is of note that, in addition to blocking 5-HT2 receptors, ketanserin has alpha1-adrenoreceptor antagonist properties. Previous data show that alpha1-adrenoreceptor antagonists inhibit 5-HT cell firing and release (Gallager and Aghajanian, 1976; Hjorth et al., 1995). However, it is unlikely that an action of ketanserin at alpha1-adrenoreceptors was significant in the present study as ketanserin alone had no effect on hippocampal 5-HT levels at the dose used.
Expression of serotonin 5-HT<inf>2C</inf> receptors in GABAergic cells of the anterior raphe nuclei
2005, Journal of Chemical NeuroanatomyOrigin and functional role of the extracellular serotonin in the midbrain raphe nuclei
2002, Brain Research Reviews