Rapid communicationEffects of phencyclidine on excitatory amino acid activation of spinal interneurones in the cat
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Phencyclidine (angel dust)/σ ‘opiate’ receptor: visualization by tritium-sensitive film
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Phencyclidine Disrupts Neural Coordination and Cognitive Control by Dysregulating Translation
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2021, Treatments, Mechanisms, and Adverse Reactions of Anesthetics and AnalgesicsArylcyclohexamines
2021, Novel Psychoactive Substances: Classification, Pharmacology and ToxicologyQuercetin Reduces Cortical GABAergic Transmission and Alleviates MK-801-Induced Hyperactivity
2018, EBioMedicineCitation Excerpt :Accurate calibration of excitatory–inhibitory balance across the central nervous system is fundamental for the normal functioning of the brain, while an imbalance in neuronal excitation/inhibition is a core feature observed in neuropsychiatric disorders, but not restricted to schizophrenia. The finding [37] that the psychotomimetic drug phencyclidine noncompetitively blocked the N-methyl-d-aspartate receptor (NMDAR) gave rise to the glutamate theory of schizophrenia [10, 11, 26], according to which NMDAR hypofunction and disturbances in NMDAR-related gene expression and metabolic pathways confer the disease phenotypes [46, 62]. The NMDAR antagonist ketamine has been shown to induce significant psychosis [31] and exacerbated it further in individuals predisposed to schizophrenia symptomatology [32].
Comparison of pro-amnesic efficacy of scopolamine, biperiden, and phencyclidine by using passive avoidance task in CD-1 mice
2017, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :For this purpose, benzodiazepines (Bertaina-Anglade, Enjuanes, Morillon, & Drieu la Rochelle, 2006; Mani et al., 2011), scopolamine (SCOP) (Jung et al., 2016; Klinkenberg & Blokland, 2011; Park et al., 2012; Salat et al., 2015; Tota, Hanif, Kamat, Najmi, & Nath, 2012; Wang et al., 2014), biperiden (BIP) (Asth, Lobão-Soares, André, Soares, & Gavioli, 2012; Kimura, Ohue, Kitaura, & Kihira, 1999; Klinkenberg & Blokland, 2011; Talpos, Aerts, Fellini, & Steckler, 2014), and phencyclidine (PCP) (Burnashev et al., 1992; Kotermanski & Johnson, 2009) (Bonito-Oliva, Dupont, Madjid, Ove Ögren, & Fisone, 2016; Gacsályi et al., 2013; Hamaguchi et al., 2014; Jones, Bauerle, & DeNoble, 1990; Oyamada et al., 2015) are used in many animal studies. Since there is a strong evidence for the involvement of cholinergic (Bainbridge et al., 2008; Blake, Krawczyk, Baratti, & Boccia, 2014; Giovannini et al., 2001; Hut & Van der Zee, 2011; Iga, Arisawa, Ise, Yasuda, & Takeshita, 1996; Miranda, Ferreira, Ramirez-Lugo, & Bermudez-Rattoni, 2003; Vishnoi, Raisuddin, & Parvez, 2016) and glutamatergic (Anis, Berry, Burton, & Lodge, 1983; Lodge & Anis, 1982; Stringer & Guyenet, 1983) systems in cognition, SCOP, BIP (non-selective and a M1-selective muscarinic receptor antagonists, respectively), and PCP (a non-competitive antagonist of the N-methyl-d-aspartate [NMDA] receptor) the drugs most frequently used are to induce amnesia under experimental conditions. Although methods involving injections of these chemicals seem to be faster, less expensive, and less complicated as compared to other protocols mentioned earlier, available literature does not indicate which of them is the most efficient one.
General Anesthetics and Neurotoxicity: How Much Do We Know?
2016, Anesthesiology Clinics