Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and γ-aminobutyric acid in amygdaloid-kindled rats
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Antiepileptic drugs as analgesics/adjuvants in inflammatory pain: current preclinical evidence
2018, Pharmacology and TherapeuticsCitation Excerpt :Receptor binding studies demonstrated that CBZ and OXC's active metabolite does not have binding affinity for GABA receptors (Marangos et al., 1983; Soares-da-Silva et al., 2015). As it was shown that CBZ can increase GABA level in some areas of the brain (Battistin, Varotto, Berlese, & Roman, 1984; Higuchi et al., 1986), it seems possible that antinociceptive/antihyperalgesic effect of CBZ/OXC is partly mediated via GABA release and activation of GABAA receptors in CNS. A non-selective 5-HT receptors antagonist (methysergide), applied systemically in a single dose, didn't influence the antinociception of systemic CBZ in rats with tooth pulp irritated and inflamed by BK (Foong & Satoh, 1984b).
Chronic central administration of valproic acid: Increased pro-survival phospho-proteins and growth cone associated proteins with no behavioral pathology
2012, Pharmacology Biochemistry and BehaviorCitation Excerpt :VPA's ability to help manage seizures is thought to be attributed to its multifaceted capability in affecting several targets. In rats, peripherally administered VPA increased the inhibitory neurotransmitter, γ-aminobutyric acid (GABA) (Godin et al., 1969; Higuchi et al., 1986; Loscher, 1981, 1999), and within the timeframe of increasing GABA, rodents were found to have decreased susceptibility towards seizures (Loscher, 1981; Schechter et al., 1978; Simler et al., 1973). Others report that VPA modulated voltage-gated sodium channels (Cunningham et al., 2003; Vreugdenhil et al., 1998), calcium influx buffering during events of glutamate-induced toxicity (Zhang et al., 2010) and lowered aspartate release (Loscher, 1999).
Alterations in somatostatin and proenkephalin mRNA in response to a single amygdaloid stimulation versus kindling
1991, Molecular Brain Research