d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors
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Role of the serotonergic system in appetite and ingestion control
2020, Handbook of Behavioral NeurosciencePrelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Corroborating our results, it has been demonstrated that administration of d-fenfluramine, a SSRI, provided evidence that 5-HT2C receptors play a critical role in mediating the inhibitory action of serotonin on feeding behavior. D-norfenfluramine, a major metabolite of d-fenfluramine, is an agonist of 5-HT2C receptors (Gibson et al., 1993). Thus, rats that were pretreated with the selective 5-HT2C receptor antagonist SB-242084 did not present the hypophagic response evoked by either d-fenfluramine or d-norfenfluramine (Vickers et al., 2001).
Serotonin controlling feeding and satiety
2015, Behavioural Brain ResearchCitation Excerpt :As the effect of d-fenfluramine was thought to be based on the increased availability of postsynaptic 5-HT, it was initially a surprising finding that inhibition of brain 5-HT synthesis with pCPA did not interfere with the hypophagic action of d-fenfluramine. Furthermore, low doses of fenfluramine do not impact on 5-HT release but already induce hypophagia [29,64]. In addition, d-fenfluramine maintains its hypophagic efficacy even following inhibition of 5-HT release [65].
Medial amygdaloid nucleus 5-HT<inf>2C</inf> receptors are involved in the hypophagic effect caused by zimelidine in rats
2012, NeuropharmacologyCitation Excerpt :Administration of d-fenfluramine, a serotonin releaser, provided the first evidence that 5-HT2C receptors play a critical role in mediating the inhibitory action of serotonin on feeding. The major metabolite of d-fenfluramine, d-norfenfluramine, is an agonist of 5-HT2C receptors (Gibson et al., 1993). Rats that were pretreated with the selective 5-HT2C receptor antagonist SB-242084 did not show a hypophagic response evoked by either d-fenfluramine or d-norfenfluramine (Vickers et al., 2001).
Estradiol increases the anorexia associated with increased 5-HT <inf>2C</inf> receptor activation in ovariectomized rats
2012, Physiology and BehaviorCitation Excerpt :Although FEN increases 5-HT neurotransmission via multiple mechanisms, its anorexigenic effect appears to be mediated primarily by its postsynaptic action. This view is supported by studies showing that FEN's anorexigenic effect is attenuated by selective blockade or targeted deletion of 5-HT2C receptors [21,22], but is unaffected by drugs that decrease 5-HT synthesis, deplete 5-HT storage, or block 5-HT reuptake [23–25]. Thus, the most parsimonious interpretation of our findings is that estradiol increases FEN's anorexigenic effect by augmenting its postsynaptic action at 5-HT2C receptors.
A role for serotonin in the antidepressant activity of N<sup>G</sup>-Nitro-L-arginine, in the rat forced swimming test
2010, Pharmacology Biochemistry and Behavior