Rapid communicationBlockade of feeding inhibition by neuromedin B using a selective receptor antagonist
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Cited by (37)
Cloning of Neuromedin B and its receptor in the rabbit and generating a polyclonal antibody to the Neuromedin B protein
2015, GeneCitation Excerpt :In the peripheral tissues and organs, NMB has a clear effect on smooth muscle contraction (Von Schrenck et al., 1989; Jensen et al., 2008). In the central nervous system (CNS), NMB has been suggested to play roles in satiety (Ladenheim et al., 1994), reproduction (Boughton et al., 2013), and thermoregulation (Ohki-Hamazaki et al., 1999), as well as in stress, fear, and other behavioral responses (Merali et al., 2006; Bedard et al., 2007; Jensen et al., 2008). Neuromedin B (NMB) functions through the activation of signaling pathways.
Insights into bombesin receptors and ligands: Highlighting recent advances
2015, PeptidesCitation Excerpt :Manipulation of BnRs could potentially have an important therapeutic role in obesity, food intake and energy/glucose metabolism (Table 3) [129,193,214,215,279,370,386,387]. This has occurred because of the demonstrated role of each of the three human BnRs, the GRPR, the NMBR and BRS-3, in regulating satiety, with evidence from both receptor knockout studies [163,249,259,370,387] and from pharmacological studies using Bn receptor agonists and antagonists [50,161,169,170,311]. Recent studies with BRS-3 have particularly highlighted this area for potential therapeutics.
Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats
2013, Regulatory PeptidesCitation Excerpt :In the periphery, NMB has well characterised effects on smooth muscle contraction [15,16], and has been reported to act as a potent inhibitor of thyroid-stimulating hormone (TSH) release from the pituitary by acting in an autocrine and/or paracrine fashion [17]. In the CNS, NMB has been suggested to play a role in satiety [18] and thermoregulation [19], as well as in stress, fear and other behavioural responses [16,20,21]. The role of NMB in the reproductive axis is poorly understood.
Bombesin
2013, Handbook of Biologically Active PeptidesGastrointestinal peptides controlling body weight homeostasis
2008, General and Comparative EndocrinologyCapsaicin treatment differentially affects feeding suppression by bombesin-like peptides
2007, Physiology and BehaviorCitation Excerpt :BN binds with equal and high affinity to both receptor subtypes. Like BN, GRP and NMB also reduce food intake when administered systemically but differ from each other, as well as from BN, in both potency and duration of action (BN > GRP > NMB) [20,21,32]. As mentioned above, BN binds both GRP and NMB receptors and thus the contribution of each to feeding suppression by BN is not known.