Merosin promotes cell attachment and neurite outgrowth and ls a component of the neurite-promoting factor of RN22 schwannoma cells☆
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Metabolic Disorders of the Brain: Part II
2011, Seminars in Ultrasound, CT and MRICitation Excerpt :Merosin is an isoform of laminin that is expressed in skeletal muscle, Schwann cells, and cardiac muscle. The merosin gene has been mapped to the laminin alpha-2 locus (LAMA2) at chromosome 6q22.68,69 Merosin-deficient CMD is a recessively inherited disorder that is the result of a mutation of the lamina-alpha-2 gene (LAMA2).
Molecular Signaling in Schwann Cell Development
2005, Peripheral Neuropathy: 2-Volume Set with Expert Consult BasicStructural Macromolecules: Laminins, Entactin/Nidogen, and Proteoglycans (Perlecan, Agrin)
2005, Current Topics in MembranesCitation Excerpt :It was first found in placental membranes (Ohno et al., 1983), in the basement membrane of Schwann cells of peripheral nerves, and in the trophoblast of placenta (Leivo and Engvall, 1988). It is a component of the neurite‐promoting factor of Schwannoma cells (Engvall et al., 1992). A variant of this laminin was found in murine and bovine hearts (Paulsson et al., 1991).
Molecular Signaling in Schwann Cell Development
2005, Peripheral NeuropathySchwann Cell Development
2004, Myelin Biology and DisordersNonmuscular involvement in merosin-negative congenital muscular dystrophy
2002, Pediatric Neurology
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This work was supported by grants from the NIH, the Swiss National Science Foundation, and Telios Pharmaceuticals, Inc.
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