Sensory nerves of the cornea and cutaneous sensibility
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Cited by (95)
Corneal nerves in health and disease
2019, Progress in Retinal and Eye ResearchCitation Excerpt :The sensory nerves exhibit a variety of afferent (e.g. pain and temperature sensation) and efferent (trophic and secretory) functions [Unlike nerves, the terms afferent and efferent for blood vessels have the opposite connotation]. Mechanical, thermal and chemical stimuli of the corneal nerves produce predominantly a sensation of pain in humans (Lele and Weddell, 1959). In some cases the maxillary division of trigeminal nerve can provide innervation to part of the inferior cornea (Ruskell, 1974; Vonderahe, 1928).
Welfare Issues in Farm Animal Ophthalmology
2010, Veterinary Clinics of North America - Food Animal PracticeCitation Excerpt :So, these free nerve endings of corneal nerves give a sensation of pain, whatever the stimulus,20 although this function has been debated for some years. Lele and Weddell21 reported that touch, warmth, and cold could be detected as well as pain, whereas Beuerman and colleagues22,23 found that any noxious sensation was felt as irritation and pain only if the cornea was stimulated. Corneal injuries provoke some degree of breakdown in the blood-aqueous barrier and the generation of a uveitic reponse,24 with this change being mediated by trigeminal stimulation mediated predominantly, but not entirely, by a prostaglandin-mediated pathway.25
Distinct central representations for sensory fibers innervating either the conjunctiva or cornea of the rat
2010, Experimental Eye ResearchCitation Excerpt :The ophthalmic division of the trigeminal nerve innervates the cornea via its long ciliary nerves. The cornea is one of the most densely innervated parts of the body (Rozsa and Beuerman, 1982; Beuerman and Pedroza, 1996; Müller et al., 2003) yet is only innervated by fibers with free nerve endings of very small diameter (Lele and Weddell, 1959; Belmonte, 1996; Belmonte et al., 1997). Moreover, stimulation of the cornea induces only sensations of irritation and pain (Belmonte, 1996; Belmonte et al., 1997; Carstens et al., 1998).
An fMRI case report of photophobia: Activation of the trigeminal nociceptive pathway
2009, PainCitation Excerpt :However, functional activation within the human trigeminal system has not yet been recorded during photophobia. Primary afferent nociceptive fibers innervate several structures of the mammalian eye, including the cornea and anterior uvea, which includes the iris and ciliary body [6,17,34]. Separate from the afferent visual pathway, afferent nociceptive innervation of the eye originates from the ophthalmic branch of the ipsilateral trigeminal ganglion [6,21,25].
Chapter 17 Cranial nerve reflexes: anatomical pathways, recording techniques and normative data
2003, Handbook of Clinical Neurophysiology
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Dr. Lele's present address is: Medical Acoustics Research Group, Massachusetts General Hospital, Boston, Massachusetts.
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Our thanks are due to Dr. Ludwig von Sallmann and Dr. W. Ross Adey for much helpful advice; and Miss Patricia Grimes for assistance in the preparation of the manuscript. This investigation was supported by a grant to one of us (G. W.) from the Rockefeller Foundation.