Ganglion cell death during normal retinal development in the chick: Comparisons with cell death induced by early target field destruction
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The Fovea: Structure, Function, Development, and Tractional Disorders
2021, The Fovea: Structure, Function, Development, and Tractional DisordersGrowth hormone-mediated survival of embryonic retinal ganglion cells: Signaling mechanisms
2008, General and Comparative EndocrinologyCitation Excerpt :In the embryonic chick eye, GH appears to be secreted from the RGCs and sequestered in the vitreous, where it is bound to proteoglycans such as opticin (Sanders et al., 2003). Embryogenesis in the avian and mammalian retina is characterized by developmentally regulated waves of cell death in several of the cell strata present, including the RGCs (Hughes and McLoon, 1979; Frade et al., 1997; Bähr, 2000; Sanders et al., 2005; Guerin et al., 2006). The presence of GH and its receptors in RGCs at the time that they are undergoing apoptosis suggests possible autocrine and/or paracrine roles for GH in the survival of these cells, because GH has established anti-apoptotic properties in other tissues (Bouzinba Segard et al., 2003; González-Juanatey et al., 2004).
Cell birth and death in the developing retina of the Brazilian opossum, Monodelphis domestica
2008, Brain ResearchCitation Excerpt :Developing nervous systems often produce an excess number of neurons that are subsequently removed by apoptosis in order to match the presynaptic elements with their appropriate targets. Apoptosis occurs in the developing retina of all vertebrate species thus far examined [fish (Biehlmaier et al., 2001; Cole and Ross, 2001; Hoke and Fernald, 1998); amphibians (Gaze and Grant, 1992; Jenkins and Straznicky, 1986); reptiles (Francisco-Morcillo et al., 2004); birds (Cook et al., 1998; Hughes and McLoon, 1979; Marin-Teva et al., 1999; Rager and Rager, 1978) and mammals (Cunningham et al., 1981; Cusato et al., 2002, 2001; Sengelaub and Finlay, 1982; Vecino et al., 2004)]. Multiple phases of cell death have been described in the retina of homeotherms.
Growth hormone and its receptor in projection neurons of the chick visual system: Retinofugal and tectobulbar tracts
2007, NeuroscienceCitation Excerpt :The immunoneutralization of endogenous GH activates caspase-3 activity, PARP-1 cleavage and the death of RGCs (Harvey et al., 2006a; Sanders et al., 2006). Cell death during the first wave of apoptosis is thought to affect neuroblasts or early postmitotic cells (Rager, 1980; Frade et al., 1997; de la Rosa and de Pablo, 2000), whereas cell death occurring during the second wave, which peaks at E12, affects mainly RGCs after they have innervated their target (Rager and Rager, 1978; Hughes and McLoon, 1979; Frade et al., 1997). The intense immunoreactivity of GH in RGC axons within the optic nerve head and the optic nerve of the retinofugal tract, as early as E5 (before the first axons reach the optic tectum, at E6), is thus highly unlikely to reflect retrograde transport of neuroprotective GH emanating from the tectum.
Retinal ganglion cell survival in development: Mechanisms of retinal growth hormone action
2006, Experimental Eye ResearchCitation Excerpt :GH is present in both the neural retina and the retinal pigmented epithelium (Harvey et al., 2003a), and is especially abundant, together with its mRNA transcripts, in the embryonic retinal ganglion cells (RGCs; Baudet et al., 2003), from which it may be secreted into the vitreous (Sanders et al., 2003). Morphogenesis in the stratified embryonic retina is characterized by precisely timed and developmentally regulated waves of apoptosis in several of the cell types present, including the RGCs (Hughes and McLoon, 1979; Frade et al., 1997; Bahr, 2000; De la Rosa and de Pablo, 2000). The presence of GH and its receptors in RGCs at the time that they are undergoing apoptosis suggests a possible autocrine and/or paracrine role for GH in the regulation of cell death in these cells.
Developmental changes in the fibre population of the optic nerve follow an avian/mammalian-like pattern in the turtle Mauremys leprosa
2006, Brain ResearchCitation Excerpt :This rich background permits one to correlate the developmental patterns of different group of vertebrates. In homothermous vertebrates (mammals and birds), the development of the retina includes the death of retinal ganglion cells (RGC) (Hughes and McLoon, 1979; Rager, 1980; Potts et al., 1982; Sengelaub and Finlay, 1982; Sengelaub et al., 1986; Dreher et al., 1983; Perry et al., 1983; Young, 1984; Dunlop and Beazley, 1987; Provis, 1987; Cook et al., 1998; Marín-Teva et al., 1999), which is associated with the loss of axons in the optic nerve (Rager, 1980; Rager and Rager, 1978; Lam et al., 1982; Ng and Stone, 1982; Perry et al., 1983; Rakic and Riley, 1983; Sefton and Lam, 1984; Crespo et al., 1985; Provis et al., 1985; Braekevelt et al., 1986; Tay et al., 1986; Williams et al., 1986; Robinson et al., 1987; Kirby et al., 1988; Langford and Sefton, 1992; for a review see Dreher and Robinson, 1988). The magnitude of RGC death is remarkably variable among vertebrates.
- 1
This work was supported by Special Visual Sciences Award NIH-EY-01477-03 to W.F.H., the Helen Regenstein Foundation, and the Louise Norton Trust.
- 2
This paper is, in part, based on a dissertation by Dr. McLoon in partial fulfillment of his requirements for the Ph.D. degree at the University of Illinois Medical Center. Dr. McLoon's present address is the Department of Anatomy, Medical University of South Carolina, 171 Ashley, Charleston, South Carolina, 29403. The authors wish to thank Mrs. Joana Aras for technical assistance and Mrs. Mary Dever for typing the final manuscript.