Spinal cord contusion in the rat: Production of graded, reproducible, injury groups☆
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Behavioral testing in animal models of spinal cord injury
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2019, Spinal Cord Injury (SCI) Repair Strategies(Chitosan-g-glycidyl methacrylate)-xanthan hydrogel implant in Wistar rats for spinal cord regeneration
2017, Materials Science and Engineering CCitation Excerpt :The rats of group 1 (with the implant) at 30 days show favorable recovery; however, they do not show full recovery, and are able to move their hindquarters in only an uncoordinated manner. In order to compare the recovery of rats, SEPS measurements are shown in Fig. 7, where it is possible to demonstrate that group 1 recovers almost the original behavior in SEP; additionally, group 1 practically showed a recovery of up to 90% according to the Wrathal test, while that of group 2 was only around 70% [27]. Thirty days after laminectomy, it is not possible to identify any SEP components in Group 2 because they are not resolved (Fig. 5); furthermore, the rats do not display any movement or signals of recovery.
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This work was supported by contract NO1-NS-2-2310 from the National Institutes of Health.