A primate model of Huntington's disease: Behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon
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2019, Neurobiology of DiseaseCitation Excerpt :In view of the complex assessments and the duration of our working hypothesis, it was ethically unacceptable to perform full lesions of both caudate and putamen bilaterally. The chosen lesion paradigm builds on the existing literature on the ability of unilateral putaminal lesions to generate motor deficits (Hantraye et al., 1990) and provides novel proof of concept of the effect of bilateral caudate lesions on cognition. Indeed, the strength of the work presented here is the in depth characterization of changes in cognitive performance and capacity to retain previously learnt rules, and the ability of lesioned NHPs to learn new rules after bilateral QA administration to the caudate nuclei.
Metabotropic glutamate receptors and neurodegenerative diseases
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