Spreading depression induces prolonged reduction of cortical blood flow reactivity in the rat
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2016, NeuroscienceCitation Excerpt :In agreement with this observation, others have reported that after the depolarization wave, CBF and oxygen levels transiently increase (Lukyanova and Bures, 1967; Piilgaard and Lauritzen, 2009). This increase in CBF is followed by a persistent decrease in blood flow (Lambert and Michalicek, 1994; Ayata et al., 2004) and oxygen levels (Piilgaard and Lauritzen, 2009) leading to a period of tissue hypoxia (Lukyanova and Bures, 1967; Lacombe et al., 1992; Otori et al., 2003; Takano et al., 2007). Therefore, in order to restore metabolic balance, cortical neurons including interneurons and astroglia are thought to release of a variety of neurotransmitters including NO, carbon monoxide, adenosine, hydrogen ions, potassium ions, and lipoxygenase products known to alter cerebral vascular tone (Vaucher et al., 2000; Zonta et al., 2003; Cauli et al., 2004; Filosa et al., 2006; Koehler et al., 2006; Busija et al., 2008).
Resting-state fMRI study of acute migraine treatment with kinetic oscillation stimulation in nasal cavity
2016, NeuroImage: ClinicalCitation Excerpt :There exist a number of theories trying to account for the ethnology of migraine. For example, inadequate regulation of the autonomic nervous system (ANS) (Ebinger et al., 2006; Geraud and Donnet, 2013; Melek et al., 2007), derangement of serotonin metabolism (Dussor, 2014; Hoffmann and Goadsby, 2014; Vollbracht and Rapoport, 2014), insensitive reaction to reduced oxygen in the vasculature and tissue (Friberg et al., 1994; Lacombe et al., 1992; Raddant and Russo, 2014), disruption of the normal pain pathways (Kroger and May, 2015), peculiar platelet metabolism (Danese et al., 2014; Gawel and Rose, 1982; Hanington, 1989), neurogenic inflammation (Tajti et al., 2015) and etc. (Alstadhaug, 2014). Researchers have yet to disseminate a unified theory to account for the different aspects of the complex pathophysiology of migraine.
Advanced neuroimaging of migraine
2009, The Lancet NeurologyCitation Excerpt :As these neuronal events occur, there are changes in cortical blood flow. A brief decrease in blood flow is followed by hyperperfusion lasting a couple of minutes and then a prolonged hypoperfusion.31–34 Recent neuroimaging has allowed detection of CSD in human beings and has raised new questions about its possible role in migraine without aura.
Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression
2008, Progress in Neurobiology