Elsevier

Life Sciences

Volume 37, Issue 18, 4 November 1985, Pages 1655-1663
Life Sciences

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The endogenous opioid system in neurological disorders of the basal ganglia

https://doi.org/10.1016/0024-3205(85)90292-9Get rights and content

Abstract

The endogenous opioid peptides have for some time been implicated in the regulation of motor behavior in animals. Recently, however, there is increased evidence to suggest a role for these peptides in the control of human motor functions as well as in the pathophysiology of abnormal movement disorders. Degeneration of opioid peptide-containing neurons in the basal ganglia has been demonstrated in Parkinson's disease and Huntington's chorea, but the clinical significance of these findings is largely unknown. On the other hand, there is evidence that excessive opioid activity may be important in the pathophysiology of some movement disorders such as tardive dyskinesia, progressive supra-nuclear palsy, and a subgroup of Tourette's patients. These findings indicate that diseases of the basal ganglia are possibly associated with alterations in opioid peptide activity, and that these alterations may be useful in designing experimental therapeutic strategies in these conditions.

References (116)

  • L. Terenius et al.

    Neuroscience Letters

    (1976)
  • D.S. Janowsky et al.

    Lancet

    (1978)
  • L. Turski et al.

    Neuropharmacology

    (1983)
  • J.S. Hong et al.

    Neuropharmacology

    (1977)
  • J.C. Schwartz

    Trends in Neurological Sciences

    (1979)
  • P. Wand et al.

    Eur. J. Pharmacol.

    (1973)
  • J. Korf et al.

    Eur. J. Pharmacol.

    (1974)
  • S.J. Bird et al.

    Brain Res.

    (1977)
  • C.J. Pycock et al.

    Neuroscience Letters

    (1981)
  • G.R. van Loon et al.

    Life Sci.

    (1978)
  • R. Dingledine et al.

    Eur. J. Pharmacol.

    (1978)
  • H.K. Lee et al.

    Brain Res.

    (1980)
  • F.V. de Feudis

    Trends in Pharmacological Sciences

    (1982)
  • S.H. Buck et al.

    Brain Res.

    (1981)
  • P.C. Emson et al.

    Brain Res.

    (1980)
  • Y. Agid et al.

    Trends in Neurological Sciences

    (1985)
  • K. Iwatsubo

    Trends in Pharmacological Sciences

    (1982)
  • B. Dahlstrom

    Life Sci.

    (1975)
  • M.A. Gillman et al.

    Psychiatry Res.

    (1985)
  • D.J. Pettibone et al.

    Brain Res.

    (1981)
  • M.E. Gold et al.

    Lancet

    (1978)
  • M.A. Gillman et al.

    Psychiatry Res.

    (1984)
  • R. Sandyk

    Medical Hypotheses

    (1985)
  • R. Sandyk

    Psychiatry Res.

    (1985)
  • M.N. Rossor et al.

    Trends in Neurological Sciences

    (1982)
  • R.M. Bowker et al.

    Brain Res.

    (1981)
  • J. Weil-Fugazza et al.

    Brain Res.

    (1979)
  • R. Sandyk et al.

    Medical Hypotheses

    (1985)
  • R. Sandyk

    Medical Hypotheses

    (1985)
  • F. Bloom et al.

    Science

    (1976)
  • C. Gramasch et al.

    Brain Res.

    (1979)
  • S.F. Atweh et al.

    Br. Med. Bull.

    (1983)
  • H. Pollard et al.

    Nature

    (1977)
  • H. Lal

    Life Sci.

    (1975)
  • E. Eidelberg et al.

    J. Pharm.

    (1975)
  • A. Brosse et al.

    Naunyn-Schmideberg's Arch. Pharmacol.

    (1976)
  • K. Iwatsubo et al.

    Characteristics and Function of Opioids

  • R.A. Nicoll et al.

    Nature

    (1980)
  • C. Llorens et al.

    Nature

    (1978)
  • S. Arbilla et al.

    Nature

    (1978)
  • C. Llorens et al.

    Nature

    (1978)
  • G.K. Aghajanian

    Nature

    (1978)
  • M. Botney et al.

    Ann. Neurol.

    (1983)
  • G. Zsilla et al.

    J. Pharmacol. Exp. Ther.

    (1976)
  • F. Moroni et al.

    Nature

    (1977)
  • K. Jhamandas et al.

    Nature

    (1977)
  • H.N. Bhargave et al.

    J. Pharmac. Exp. Ther.

    (1972)
  • S.H. Buck et al.

    Gilles de la Tourette syndrome

  • C. Llorens-Cortes et al.

    Journal of Neurochemistry

    (1984)
  • H.H. Loh et al.

    Nature

    (1976)
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