MinireviewThe endogenous opioid system in neurological disorders of the basal ganglia
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Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome
2013, PainCitation Excerpt :Prior evidence implicates the GP in the modulation and behavioral responses to pain. Specifically, the GP has been shown to be involved in modulation of pain via the endogenous opioid system [18,31,61], and bilateral stimulation of this region has been shown to decrease chronic pain in patients with dystonia [27,30,45]. Thus, the DTI changes observed in the current study appear consistent with the repeated activation of the GP associated with the recurrent experience of abdominal pain, resulting in an increase in the number of dendritic arborizations without a corresponding increase in the coherence of fiber directionality.
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