Elsevier

Life Sciences

Volume 39, Issue 21, 24 November 1986, Pages 2033-2036
Life Sciences

Opiate actions on mesocortical dopamine metabolism in the rat

https://doi.org/10.1016/0024-3205(86)90327-9Get rights and content

Abstract

The actions of parenteral morphine were examined with regard to dopamine metabolism in the mesocortical dopaminergic pathways of the rat. The effects of morphine on dopamine metabolism in the prefrontal, cingulate, pyriform and entorhinal cortices were compared with the actions of morphine on the metabolism of dopamine in the striatum and olfactory tubercle. In all tissues, except the entortinal cortex, morphine significantly elevated the dopamine metabolites dihydroxyphenylacetic acid and homovanillic acid. These data, along with previous studies of various pharmacological agents, clearly indicate that the mesocortical dopaminergic projections possess unique opioid and non-opioid regulatory inputs.

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