ICV-CRH potently affects behavior without altering antinociceptive responding
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Cited by (36)
Anxiolytic effect of the GPR103 receptor agonist peptide P550 (homolog of neuropeptide 26RFa) in mice. Involvement of neurotransmitters
2016, PeptidesCitation Excerpt :Takayasu et al. demonstrated that 43RFa – an endogenous ligand of the GPR103 receptor – increased significantly the general locomotor activity and the number of grooming bouts as well as the time spent in grooming in mice [34]. The exploratory behavior (locomotion) and the stereotyped behavior (grooming) are under the control of Corticotropin-releasing hormone (CRH) release, especially through the activation of the mesolimbic CRH1 receptor system [1,21,31,33]. Therefore, one can presume that 43RFa may increase the CRH release and stimulate the hypothalamic–pituitary–adrenal (HPA) axis.
The actions of neuropeptide SF on the hypothalamic-pituitary-adrenal axis and behavior in rats
2013, Regulatory PeptidesCitation Excerpt :In conclusion, our data suggest that centrally released NPSF, acting at the paraventricular nucleus [38] stimulates CRH secretion. This, in turn, leads to ACTH secretion and also modulates, although in different manner than other PQRFamides, the accompanying behavioral phenomena related to the stress response [39,40]. Further studies are necessary, however, to clarify the signal transduction processes of individual PQRFamides, separate their distinct activities and outline the physiological profile of NPFF and NPVF on the HPA axis and behavior.
CRH: The link between hormonal-, metabolic- and behavioral responses to stress
2013, Journal of Chemical NeuroanatomyCitation Excerpt :Furthermore, CRH overexpressing mice also display a behavioral phenotype seen in stressed animals including increased anxiety (Kasahara et al., 2007; Stenzel-Poore et al., 1996). CRH increases locomotion in a familiar surroundings, decreases exploration in novel environment, induces grooming, burrowing, self-gnawing and decreases rearing and sleeping (Sherman and Kalin, 1986), however does not affect analgesia. Some of these behaviors (grooming and exploration) can be initiated by CRH microinjections into the amygdala under resting conditions (Wiersma et al., 1995).
Atrazine does not induce pica behavior at doses that increase hypothalamic-pituitary-adrenal axis activation and cause conditioned taste avoidance
2012, Neurotoxicology and TeratologyCitation Excerpt :For example, activation of the HPA-axis through intracerebroventricular (ICV) injection of corticotrophin releasing factor (CRF) causes a percentage increase in CORT release that is similar during both the light and dark phases (Atkinson et al., 2006; Dubovicky et al., 2007). In addition, activation of the HPA-axis with ICV administration of CRF during the dark phase is effective in inducing pica behavior and decreases in food intake, despite the presence of already elevated diurnal CORT concentrations (Sherman and Kalin, 1986; Morley and Levine, 1982). This suggests that although diurnal serum levels of CORT were high at the time of behavioral testing, alterations in pica behavior and food intake resulting from the administration of ATR or DACT were reliably detected during this period.
Endocrine, behavioral and autonomic effects of neuropeptide AF
2009, Hormones and BehaviorEndocrine and behavioral effects of neuromedin S
2007, Hormones and Behavior