Muscarinic receptor subtypes in airways
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2022, Life SciencesCitation Excerpt :They are also present in airway smooth muscle and counteract the bronchodilator action of β-agonists. Contractile responses in airway smooth muscles are mediated through M3 receptors, a subtype of muscarinic receptors that are also present on the submucosal gland and epithelial cells in the human airway [69]. Muscarinic receptors are the therapeutic target for many lung diseases such as asthma and COPD [70].
Treatment with long acting muscarinic antagonists stimulates serum levels of irisin in patients with COPD
2018, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Long-acting muscarinic antagonists (LAMA) in combination with long-acting beta2-agonists are increasingly being used to treat chronic obstructive pulmonary disease (COPD) due to greater improvement in lung function and symptom scores [1–5]. Both classes of bronchodilators relax airway smooth muscle and thereby reduce respiratory muscle activity and dynamic hyperinflation and improve ventilatory mechanics [6–8]. In patients with COPD, the use of LAMA, as compared to placebo, reduced lung hyperinflation and inspiratory capacity at rest and during exercise contributing to improvement in exertional dyspnea and increased exercise endurance [8].
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