Elsevier

Neuropharmacology

Volume 18, Issues 8–9, August–September 1979, Pages 673-678
Neuropharmacology

Release of acetylcholine from the hippocampus of freely moving rats during sensory stimulation and running

https://doi.org/10.1016/0028-3908(79)90034-0Get rights and content

Abstract

The release of acetylcholine (ACh) from the dorsal hippocampus and sensorimotor cortex was measured during sensory stimulation and motor behavior in freely moving rats and under urethane anesthesia. Released ACh was collected by means of a constant perfusion apparatus. There was a significant increase in ACh release from the hippocampus during sensory stimulation and running but the cortical release was not significantly changed. Systemic administration of atropine sulfate did not change the increase in hippocampal release due to sensory stimulation and motor activity in freely moving rats, but it blocked the increase in ACh release due to sensory stimulation under urethane anesthesia. Both acute and chronic septal lesions abolished the increase of ACh due to sensory stimulation and running and the chronic lesions also reduced the resting release of ACh from the hippocampus. Results show that both sensory and motor behavior activates the septo-hippocampal cholinergic tract but only the activation resulting from sensory stimulation is abolished by atropine. This suggests that different pathways activate the septum during sensory stimulation and motor activity.

References (22)

  • A.M. Goldberg et al.

    The determination of picomole amounts of acetylcholine in mammalian brain

    J. Neurochem.

    (1973)
  • Cited by (152)

    • Brain areas that influence general anesthesia

      2014, Progress in Neurobiology
      Citation Excerpt :

      Ach release in the neocortex, largely derived from the basal forebrain, is known to increase during waking and REMS as compared to SWS (Phyllis, 2005). Release of Ach in the hippocampus was highest during walking as compared to immobility awake or SWS (Dudar et al., 1979). Identified cholinergic neurons in the NB fired maximally during active waking and REMS (Fig. 2A; Lee et al., 2005a).

    View all citing articles on Scopus

    Present address: Department Psychology, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada.

    View full text