Higher susceptibility of taurine-deficient rats to seizures induced by 4-aminopyridine
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Cited by (22)
Taurine and epilepsy
2013, Epilepsy ResearchCitation Excerpt :Reduction in brain taurine content by the transport inhibitor guanidinoethanesulfonate in mice has likewise not affected the convulsions evoked by maximal electroshocks (Izumi et al., 1985). However, the seizure threshold to excitatory 4-aminopyridine is lowered in taurine-deficient rats (Pasantes-Morales et al., 1987). In more recent studies intravenous 0.95 μmol taurine has inhibited wet-dog shakes and hippocampal seizures induced by opioid peptides in rats (Izumi et al., 1987).
Changes in plasma concentration of taurine in stroke
2011, Neuroscience LettersCitation Excerpt :There was also no correlation between plasma taurine and other biochemical parameters such as Mg, Ca, and phosphate. Pasanet-Morales et al. [34] showed a greater susceptibility to seizures in taurine-deficient rats, as demonstrated by a lowered latency for clonic seizures, an increased incidence of tonic seizures and a higher postseizure mortality. They suggested an involvement of endogenous taurine in nervous excitability.
Simultaneous glutamate and EEG activity measurements during seizures in rat hippocampal region with the use of an electrochemical biosensor
2008, Journal of Neuroscience MethodsActivation of GABA<inf>A</inf> receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons
2005, NeuropharmacologyCitation Excerpt :Of special interest, low levels of taurine and GABA have been reported in the brains of AD patients (e.g., Pomara et al., 1992; Csernansky et al., 1996). Impairments in taurinergic tonus have also been implicated in several pathological conditions, including the loss of taurine from epileptic foci in humans (Perry and Hansen, 1981) and a higher susceptibility of taurine-deficient rats to seizures (Pasantes-Morales et al., 1987). The observations outlined above suggest that administration of taurine may provide a novel therapeutic approach in the prevention and/or treatment of Aβ- and glutamate-induced neurotoxicity in AD.
Feline retinal ultrastructural changes induced by a high cystine diet
1990, Nutrition Research