Elsevier

Physiology & Behavior

Volume 22, Issue 1, January 1979, Pages 139-147
Physiology & Behavior

Tactile discrimination performance deficits following neglect-producing unilateral lateral hypothalamic lesions in the rat

https://doi.org/10.1016/0031-9384(79)90415-3Get rights and content

Abstract

Unilateral lesions of the lateral hypothalamus (LH) which produced pronounced asymmetries on a battery of neurologic tests also produced a pattern of deficits on three appetitive tactile discrimination tasks which suggested a response deficit rather than “sensory neglect.” Deprived rats trained to turn toward a gentle touch to the flank to obtain sugar water were selectively impaired only when touches were presented contralateral to the lesion. A second group of rats trained to turn away from the side of the touch was only impaired when the touch was ipsilateral (and the response contralateral) to the lesion. A third group of rats trained to make the same forward-directed response following a touch on either flank was not impaired when either side was touched. Thus, across the three tasks, performance on trials in which touches were contralateral to the lesion was not impaired unless the response was also contralateral, and contralateral responses were always impaired regardless of where the touch occurred.

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    This research was supported by PHS grants MH 26973 and S05 RR 7031 to Gabriel P. Frommer. A shorter version of this research was presented at the Society for Neuroscience meetings, 1977 [18].

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