Adinazolam both prevents and reverses the long-term reduction of daily activity produced by inescapable shock☆
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The role of the central noradrenergic system in behavioral inhibition
2011, Brain Research ReviewsCitation Excerpt :Behavioral activation responses in animals, which appear analogous to human daily activities, may be modeled in animals using measures of gross behavioral responses to novel or appetitive stimuli, such as exposure to a nonthreatening fresh cage or running wheel, performance of appetitive operant responses or initial escape responses to swim stress. Much previous work has shown that chronic stress, which is etiologically linked to depression in humans, reduces behavioral activation in most or all of these conditions (Garcia-Garcia et al., 2009; Maier et al., 1990; Pechlivanova et al., 2010; Roth and Katz, 1981; Stone et al., 2007) and that these deficits are selectively reversed by antidepressant agents (Farley et al., 2010; Roth and Katz, 1981; Surget et al., 2009). The present review is therefore based on studies utilizing measures of these responses.
Acute reversible inactivation of the ventral medial prefrontal cortex induces antidepressant-like effects in rats
2010, Behavioural Brain ResearchThe consequences of uncontrollable stress are sensitive to duration of prior wheel running
2005, Brain ResearchCitation Excerpt :LH behaviors include impaired escape performance [77,84] and exaggerated fear conditioning [61]. Interestingly, as well as being prevented or reversed by antidepressant and anxiolytic drugs [64,66,69,72], LH behaviors are sensitive to the physical activity status of the organism. Six or more weeks of voluntary access to running wheels prior to exposure to uncontrollable shocks protects rats from developing LH [23,42,74].
Alpha-1-noradrenergic neurotransmission, corticosterone, and behavioral depression
1999, Biological PsychiatryBenzodiazepines as antidepressants: Does GABA play a role in depression?
1995, Biological Psychiatry
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This research was supported by the Upjohn Company, NSF Grant BNS 88-09527, and RSDA MH 00314.